In a society where physical activity is limited and food supply is abundant, metabolic
diseases are becoming a serious epidemic. Metabolic syndrome (MetS) represents a cluster …

Obesity is a major public health problem worldwide, and it is associated with an increased
risk of developing type 2 diabetes. It is now commonly accepted that chronic inflammation …

Background As the disease progresses, many patients with type 2 diabetes have difficulty in
reaching treatment goals. We aimed to assess the efficacy and safety of tirzepatide, a novel …

Abstract Type 2 diabetes (T2D) is a heterogeneous disease that develops through diverse
pathophysiological processes, and molecular mechanisms that are often specific to cell …

Background Given the unique phenotype of type 2 diabetes in Japanese patients, novel
therapies such as oral semaglutide require evaluation in this population. PIONEER 9 aimed …

Background New glucose-lowering medications need to be investigated in east Asian
populations, as the clinical characteristics of type 2 diabetes differ between western and east …

As the aglycone of phloridzin, phloretin belongs to dihydrochalcone with antioxidant, anti-
inflammatory and antimicrobial activities. In this study, multispectroscopic techniques and …

Aims To evaluate the efficacy and safety of imeglimin for up to 52 weeks as combination
therapy with insulin in Japanese patients with type 2 diabetes. Materials and Methods This …

Background The sodium-glucose co-transporter-2 (SGLT-2) inhibitors have been reported to
increase both low-density lipoprotein (LDL) and high-density lipoprotein (HDL)-cholesterol …

Abstract Type 2 diabetes in East Asians is characterized primarily by β‐cell dysfunction, and
with less adiposity and less insulin resistance compared with that in Caucasians. Such …