Ciprofloxacin is a broad spectrum fluoroquinolone antibacterial agent. Since its introduction
in the 1980s, most Gram-negative bacteria have remained highly susceptible to this agent in …

Much early experience with antibiotic therapy involved oral administration of sulfonamides,
penicillins, tetracyclines, and chloramphenicol. Newer acid-labile, less-soluble agents …

Background. Hospitalization and intravenous (IV) broad‐spectrum antibiotics are the
standard of care for all febrile neutropenic patients with cancer. Recent work suggests that a …

PURPOSE: We recently demonstrated the efficacy of single-agent oral ofloxacin in the
management of hospitalized neutropenic febrile patients. Ofloxacin was particularly effective …

In an attempt to determine the actual relevance of Pseudomonas aeruginosa as a target of
empiric antimicrobial first-line therapy in febrile cancer patients, 44 reports of clinical trials on …

Background Fever occurring in a neutropenic patient remains a common life‐threatening
complication of cancer chemotherapy. The common practice is to admit the patient to …

Neutrophils play an important role in immunological function. Neutropenic patients are
vulnerable to infection, and except fever is present, inflammatory reactions are scarce in …

Standard management of febrile neutropenia includes the prompt administration of
empirical, broad-spectrum, parenteral antibiotic therapy. This is generally done in a hospital …

Prompt treatment with empirical antibiotics in neutropenic febrile patients reduces morbidity
and mortality. Most patients have been treated with parenteral combination antibiotics, but …

Progress has been made in the development and validation of rules that attempt ito predict a
low risk (< 10%) of severe infection or clinical complications in patients with cancer, fever …