Epstein-Barr virus as a cause of multiple sclerosis: opportunities for prevention and therapy

F Aloisi, G Giovannoni, M Salvetti - The Lancet Neurology, 2023 - thelancet.com
Multiple sclerosis is a chronic inflammatory disease of the CNS that results from the interplay
between heritable and environmental factors. Mounting evidence from different fields of …

[HTML][HTML] The role of Epstein-Barr virus in multiple sclerosis: from molecular pathophysiology to: in vivo: imaging

Y Guan, D Jakimovski, M Ramanathan… - Neural regeneration …, 2019 - journals.lww.com
Multiple sclerosis (MS) is a disease of the central nervous system characterized by
inflammation, demyelination, and neuronal damage. Environmental and genetic factors are …

[HTML][HTML] The CD8 T cell-Epstein-Barr virus-B cell trialogue: a central issue in multiple sclerosis pathogenesis

C Veroni, F Aloisi - Frontiers in immunology, 2021 - frontiersin.org
The cause and the pathogenic mechanisms leading to multiple sclerosis (MS), a chronic
inflammatory disease of the central nervous system (CNS), are still under scrutiny. During …

[HTML][HTML] Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells

A Hassani, JR Corboy, S Al-Salam, G Khan - PloS one, 2018 - journals.plos.org
Multiple sclerosis (MS) is a chronic neuroinflammatory condition of the central nervous
system (CNS). It is a major cause of neurological disability in young adults, particularly …

Defective T‐cell control of Epstein–Barr virus infection in multiple sclerosis

MP Pender, PA Csurhes, JM Burrows… - Clinical & …, 2017 - Wiley Online Library
Mounting evidence indicates that infection with Epstein–Barr virus (EBV) has a major role in
the pathogenesis of multiple sclerosis (MS). Defective elimination of EBV‐infected B cells by …

Epstein-Barr virus-specific CD8 T cells selectively infiltrate the brain in multiple sclerosis and interact locally with virus-infected cells: clue for a virus-driven …

B Serafini, B Rosicarelli, C Veroni, GA Mazzola… - Journal of …, 2019 - Am Soc Microbiol
Epstein-Barr virus (EBV) is a ubiquitous herpesvirus strongly associated with multiple
sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS) …

[HTML][HTML] Infection as an environmental trigger of multiple sclerosis disease exacerbation

AJ Steelman - Frontiers in immunology, 2015 - frontiersin.org
Over the past several decades, significant advances have been made in identifying factors
that contribute to the pathogenesis of multiple sclerosis (MS) and have culminated in the …

Viruses and endogenous retroviruses in multiple sclerosis: From correlation to causation

AFA Mentis, E Dardiotis, N Grigoriadis… - Acta Neurologica …, 2017 - Wiley Online Library
Multiple sclerosis is an immune‐mediated disease with an environmental component.
According to a long‐standing but unproven hypothesis dating to initial descriptions of …

Expanded T lymphocytes in the cerebrospinal fluid of multiple sclerosis patients are specific for Epstein-Barr-virus-infected B cells

A Gottlieb, HPT Pham, JG Saltarrelli… - Proceedings of the …, 2024 - National Acad Sciences
Epstein–Barr virus (EBV) infection has long been associated with multiple sclerosis (MS),
but the role of EBV in the pathogenesis of MS is not clear. Our hypothesis is that a major …

MINI-review of Epstein-Barr virus involvement in multiple sclerosis etiology and pathogenesis

F Aloisi, AH Cross - Journal of Neuroimmunology, 2022 - Elsevier
Epstein-Barr virus (EBV) is the infectious agent that shows the strongest association with
multiple sclerosis (MS). EBV is a ubiquitous double stranded DNA herpes virus that …