Human epidermal growth factor receptor 2 (HER2) is a member of the epidermal growth
factor receptor family having tyrosine kinase activity. Dimerization of the receptor results in …

Human epidermal growth factor receptor 2 (HER2) is overexpressed in around 20–30% of
breast cancer tumors. It is associated with a more aggressive disease, higher recurrence …

The HER-2/neu oncogene is a member of the erb B-like oncogene family, and is related to,
but distinct from, the epidermal growth factor receptor. This gene has been shown to be …

Human epidermal growth factor receptor 2 (HER2) is involved in the pathogenesis and poor
outcomes of several types of cancer, including advanced gastric and gastroesophageal …

Runx3/Pebp2αC null mouse gastric mucosa exhibits hyperplasias due to stimulated
proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to …

Antibodies were raised against a synthetic peptide corresponding to 14 amino acid residues
at the COOH-terminus of a protein deduced from the human c-erb B-2 nucleotide sequence …

The HER2/c-erbB-2 gene encodes the epidermal growth factor receptorlike human homolog
of the rat neu oncogene. Amplification of this gene in primary breast carcinomas has been …

A wide variety of human tumors contain an amplified or overexpressed erb B-2 gene, which
encodes a growth factor receptor-like protein. When erb B-2 complementary DNA was …

Human epidermal growth factor receptor 2 (HER2) receptor tyrosine kinase is
overexpressed in 20–30% of breast cancers and is associated with poor prognosis and …

We have examined whether inhibition of phosphatidylinositol-3 kinase (PI3K) and its target,
the serine/threonine kinase Akt, play a role in the antitumor effect of the HER2 antibody …