It has recently become apparent that RNA, itself the product of transcription, is a major
regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs) …

Telomeres, the ends of linear eukaryotic chromosomes, are characterized by the presence
of multiple repeats of a short DNA sequence. This telomeric DNA is protected from illicit …

Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Telomeres with G-rich repetitive DNA and particular proteins as special heterochromatin
structures at the termini of eukaryotic chromosomes are tightly maintained to safeguard …

Budding yeast, like other eukaryotes, carries its genetic information on chromosomes that
are sequestered from other cellular constituents by a double membrane, which forms the …

Novel RNA-guided cellular functions are paralleled by an increasing number of RNA-
binding proteins (RBPs). Here we present 'serial RNA interactome capture'(serIC), a multiple …

The DNA-dependent protein kinase (DNA-PK), which comprises the KU heterodimer and a
catalytic subunit (DNA-PKcs), is a classical non-homologous end-joining (cNHEJ) factor. KU …

Telomerase adds simple-sequence repeats to the ends of linear chromosomes to counteract
the loss of end sequence inherent in conventional DNA replication. Catalytic activity for …

The long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome
ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency …