Abstract Overactive phosphoinositide 3-kinase (PI3K) in cancer and immune dysregulation
has spurred extensive efforts to develop therapeutic PI3K inhibitors. Although progress has …

The phosphatidylinositol 3–kinase (PI3K) signaling pathway is involved in a broad range of
cellular processes, including growth, metabolism, differentiation, proliferation, motility, and …

We report the updated classification of Inborn Errors of Immunity/Primary
Immunodeficiencies, compiled by the International Union of Immunological Societies Expert …

Very early onset inflammatory bowel disease (VEO-IBD) is defined as IBD presenting before
6 years of age. When compared with IBD diagnosed in older children, VEO-IBD has some …

Infection of T cells by Epstein-Barr virus (EBV) causes chronic active EBV infection (CAEBV)
characterized by T cell lymphoproliferative disorders (T-LPD) of unclear etiology. Here, we …

The phosphoinositide 3-kinase (PI3K) pathway regulates diverse cellular processes, with
finely tuned PI3Kδ activity being crucial for immune cell development and function. Genetic …

Abstract Activated phosphatidylinositol 3-kinase-δ (PI3K-δ) syndrome (APDS) is a rare
primary combined immunodeficiency caused by either dominant gain-of-function mutations …

Abstract Activated phosphoinositide-3-kinase (PI3K) δ syndrome (APDS) is an inborn error
of immunity characterised by immune dysregulation. Since the discovery of genetic …

Abstract “This porridge is too hot!” she exclaimed. So, she tasted the porridge from the
second bowl.“This porridge is too cold,” she said. So, she tasted the last bowl of …

PI3K signalling is required for activation, differentiation, and trafficking of T cells. PI3Kδ, the
dominant PI3K isoform in T cells, has been extensively characterised using PI3Kδ mutant …