Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

Nanoparticles with multifunctionality are being designed and formulated to overcome
various limitations of drugs as well as conventional drug delivery systems. Engineered …

The application of nanotechnology to medicine, usually termed nanomedicine, has given a
crucial impulse to the design of various drug-loaded nanocarriers driven by the aim to …

Resistance to cancer therapies has been a commonly observed phenomenon in clinical
practice, which is one of the major causes of treatment failure and poor patient survival. The …

Polymeric micelles are a prevalent topic of research for the past decade, especially
concerning their fitting ability to deliver drug and diagnostic agents. This delivery system …

Cisplatin (CDDP) is a widely used chemotherapeutic drug with proven efficacy for treating
tumors. However, its use has been associated with severe side effects and eventually leads …

Recently, it has been discovered that the PEG layer on nanoparticle surface can create
steric hindrance, preventing efficient cellular uptake of PEGylated nanoparticles. Thus, it …

Polymeric micelles (PMs) play a vital role in multidrug co-delivery and cancer treatment.
However, development of intelligent PMs further allows PMs to accurately target tumour …

Nanoparticles (NPs) are atomic clusters of crystalline or amorphous structure that possess
unique physical and chemical properties associated with a size range of between 1 and 100 …