[HTML][HTML] Determinants and outcomes of mitochondrial dynamics

R Quintana-Cabrera, L Scorrano - Molecular Cell, 2023 - cell.com
Mitochondria are not only central organelles in metabolism and energy conversion but are
also platforms for cellular signaling cascades. Classically, the shape and ultrastructure of …

[HTML][HTML] Mitochondrial fusion and fission: The fine-tune balance for cellular homeostasis

M Adebayo, S Singh, AP Singh… - FASEB journal: official …, 2021 - ncbi.nlm.nih.gov
Mitochondria are highly dynamic, maternally inherited cytoplasmic organelles, which fulfill
cellular energy demand through the oxidative phosphorylation system. Besides, they play an …

The cell biology of mitochondrial membrane dynamics

M Giacomello, A Pyakurel, C Glytsou… - Nature reviews Molecular …, 2020 - nature.com
Owing to their ability to efficiently generate ATP required to sustain normal cell function,
mitochondria are often considered the 'powerhouses of the cell'. However, our …

Mitochondrial dynamics and its involvement in disease

DC Chan - Annual review of pathology: mechanisms of disease, 2020 - annualreviews.org
The dynamic properties of mitochondria—including their fusion, fission, and degradation—
are critical for their optimal function in energy generation. The interplay of fusion and fission …

Mitochondrial fusion: the machineries in and out

S Gao, J Hu - Trends in cell biology, 2021 - cell.com
Mitochondria are highly dynamic organelles that constantly undergo fission and fusion.
Disruption of mitochondrial dynamics undermines their function and causes several human …

Mitochondrial dynamics: overview of molecular mechanisms

L Tilokani, S Nagashima, V Paupe… - Essays in …, 2018 - portlandpress.com
Mitochondria are highly dynamic organelles undergoing coordinated cycles of fission and
fusion, referred as 'mitochondrial dynamics', in order to maintain their shape, distribution and …

Mitochondrial dynamics in health and disease

NMB Yapa, V Lisnyak, B Reljic, MT Ryan - FEBS letters, 2021 - Wiley Online Library
In animals, mitochondria are mainly organised into an interconnected tubular network
extending across the cell along a cytoskeletal scaffold. Mitochondrial fission and fusion, as …

[HTML][HTML] Mitochondrial fission and fusion: A dynamic role in aging and potential target for age-related disease

YJ Liu, RL McIntyre, GE Janssens… - Mechanisms of ageing …, 2020 - Elsevier
The mitochondria is the major hub to convert energy for cellular processes. Dysregulation of
mitochondrial function is one of the classical hallmarks of aging, and mitochondrial …

Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy

GL McLelland, T Goiran, W Yi, G Dorval, CX Chen… - Elife, 2018 - elifesciences.org
Despite their importance as signaling hubs, the function of mitochondria-ER contact sites in
mitochondrial quality control pathways remains unexplored. Here we describe a mechanism …

Mitofusin 2: from functions to disease

R Filadi, D Pendin, P Pizzo - Cell death & disease, 2018 - nature.com
Mitochondria are highly dynamic organelles whose functions are essential for cell viability.
Within the cell, the mitochondrial network is continuously remodeled through the balance …