Global prevalence of SARS-CoV-2 3CL protease mutations associated with nirmatrelvir or ensitrelvir resistance

JD Ip, AWH Chu, WM Chan, RCY Leung… - …, 2023 - thelancet.com
Summary Background Nirmatrelvir-ritonavir (Paxlovid) and ensitrelvir are 3-chymotrypsin-
like cysteine protease (3CL pro) inhibitors which have been approved for the treatment of …

Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents

A Khadilkar, ZL Bunch, J Wagoner… - Journal of natural …, 2023 - ACS Publications
Botanical natural products have been widely consumed for their purported usefulness
against COVID-19. Here, six botanical species from multiple sources and 173 isolated …

Molecular epidemiology of SARS-CoV-2 omicron sub-lineages isolated from Turkish patients infected with COVID-19

M Sayan, A Arikan, E Sanlidag - Viruses, 2023 - mdpi.com
Early detection and characterization of new variants and their impacts enable improved
genomic surveillance. This study aims to evaluate the subvariant distribution of Omicron …

Paxlovid-like nirmatrelvir/ritonavir fails to block SARS-CoV-2 transmission in ferrets

RM Cox, CM Lieber, JD Wolf, A Karimi, NAP Lieberman… - bioRxiv, 2022 - biorxiv.org
Despite the continued spread of SARS-CoV-2 and emergence of variants of concern (VOC)
that are capable of escaping preexisting immunity, therapeutic options are underutilized. In …

Genomic tracking of SARS-COV-2 variants in Myanmar

KZ Oo, ZW Htun, NM Aung, KK Win, KZ Linn, SP Htoo… - Vaccines, 2022 - mdpi.com
In December 2019, the COVID-19 disease started in Wuhan, China. The WHO declared a
pandemic on 12 March 2020, and the disease started in Myanmar on 23 March 2020. In …