Although the interest in the septohippocampal (SH) pathway is not recent [see the series of
papers by Petsche and co-workers in the 1960s (436, 437)], its study has been hampered for …

This brief review will focus on a new hypothesis for the role of epigenetic mechanisms in
aging-related disruptions of synaptic plasticity and memory. Epigenetics refers to a set of …

Young adult rats with bilateral lesions to the hippocampus or prefrontal cortex, young
operated controls, and normal old rats were tested on two complex mazes in the Hebb …

Two experiments are reported in which young and old rats, housed in an impoverished (IE),
enriched,(EE), or standard (SE), environment, were tested on a series of complex, blind …

We have developed the Stone maze paradigm for use as a rat model of memory impairment
observed in normal aging and in Alzheimer's disease. Evidence produced thus far clearly …

The 14-unit T-maze has proven to be a valuable tool for investigating age-associated
memory impairment (AAMI). While another task widely used to evaluate AAMI, the water …

To determine the involvement of the N-methyl-D-aspartate (NMDA) receptor in shock-
motivated complex maze performance, the drug dizocilpine (DIZO; aka MK-801) was …

Abstract Phenserine ((−)-N-phenylcarbamoyl eseroline), a carbamate analog of
physostigmine (Phy), is a long-acting inhibitor of cholinesterase. We have assessed the …

The present study investigated whether spatial performance in the Morris water maze
(MWM) recovers after bilateral transection of the fimbria/fornix (FF) in rats, whether such …

Scopolamine was utilized to assess cholinergic muscarinic blockade on the performance of
young (3 months) and aged (23 months) male F-344 rats in a 14-unit T-maze task. Prior to …