Targeting PI3K/AKT/mTOR signaling pathway in breast cancer
Simple Summary PI3K signaling pathway plays an essential role in many cellular processes
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …
and is frequently altered in breast cancer, leading to increased tumor growth and reduced …
[HTML][HTML] Efficacy of PI3K inhibitors in advanced breast cancer
B Verret, J Cortes, T Bachelot, F Andre, M Arnedos - Annals of Oncology, 2019 - Elsevier
Abstract The phosphoinositide 3 (PI3)-kinase/Akt signaling pathway has always been a
focus of interest in breast cancer due to its role in cell growth, cell proliferation, cell migration …
focus of interest in breast cancer due to its role in cell growth, cell proliferation, cell migration …
PIK3CA-mutations in breast cancer
K Reinhardt, K Stückrath, C Hartung, S Kaufhold… - Breast Cancer Research …, 2022 - Springer
Abstract Purpose Phosphatidylinositide-3-kinase (PI3K) regulates proliferation and
apoptosis; somatic PIK3CA-mutations may activate these processes. Aim of this study was to …
apoptosis; somatic PIK3CA-mutations may activate these processes. Aim of this study was to …
New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer
SX Yang, E Polley, S Lipkowitz - Cancer treatment reviews, 2016 - Elsevier
Abstract PI3K/AKT signaling pathway plays an important role in tumorigenesis and regulates
critical cellular functions including survival, proliferation and metabolism. PIK3CA mutations …
critical cellular functions including survival, proliferation and metabolism. PIK3CA mutations …
PI3K mutations in breast cancer: prognostic and therapeutic implications
T Mukohara - Breast Cancer: Targets and Therapy, 2015 - Taylor & Francis
The PI3K pathway is the most frequently enhanced oncogenic pathway in breast cancer.
Among mechanisms of PI3K enhancement, PIK3CA mutations are most frequently (∼ 30%) …
Among mechanisms of PI3K enhancement, PIK3CA mutations are most frequently (∼ 30%) …
Systematic identification of mutations and copy number alterations associated with cancer patient prognosis
JC Smith, JM Sheltzer - elife, 2018 - elifesciences.org
Successful treatment decisions in cancer depend on the accurate assessment of patient risk.
To improve our understanding of the molecular alterations that underlie deadly …
To improve our understanding of the molecular alterations that underlie deadly …
[HTML][HTML] Overview of the relevance of PI3K pathway in HR-positive breast cancer
One of the hallmarks of hormone receptor (HR)-positive breast cancer is its dependence on
the phosphatidylinositol-3-kinase (PI3K) pathway. Here, we review the epidemiologic …
the phosphatidylinositol-3-kinase (PI3K) pathway. Here, we review the epidemiologic …
Endocrine-resistant breast cancer: mechanisms and treatment
AD Hartkopf, EM Grischke, SY Brucker - Breast care, 2020 - karger.com
Background: Endocrine treatment is one of the most effective therapies for estrogen receptor-
positive breast cancer. However, most tumors will develop resistance to endocrine therapy …
positive breast cancer. However, most tumors will develop resistance to endocrine therapy …
INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer
SJ Rodgers, LM Ooms, VMJ Oorschot… - Nature …, 2021 - nature.com
Abstract INPP4B suppresses PI3K/AKT signaling by converting PI (3, 4) P2 to PI (3) P and
INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is …
INPP4B inactivation is common in triple-negative breast cancer. Paradoxically, INPP4B is …
[HTML][HTML] Principles of digital PCR and its applications in current obstetrical and gynecological diseases
X Mao, C Liu, H Tong, Y Chen, K Liu - American journal of …, 2019 - ncbi.nlm.nih.gov
Digital PCR (dPCR) is a revolutionary technique to precisely quantify nucleic acids. For its
high sensitivity and specificity, this technique has been widely replicated worldwide. To …
high sensitivity and specificity, this technique has been widely replicated worldwide. To …