The development of malignant disease might be seen as a failure of immune surveillance.
However, not all tumors are naturally immunogenic, and even among those that are …

Since the introduction of organ transplantation into medical practice, progress and optimism
have been abundant. Improvements in immunosuppressive drugs and ancillary care have …

Five patients with end-stage renal disease received combined bone marrow and kidney
transplants from HLA single-haplotype mismatched living related donors, with the use of a …

Exciting results reporting that blockade of the CD40/CD40 ligand pathway by monoclonal
antibody against CD40 ligand led to long-term acceptance of renal allografts in monkeys …

We report here the long-term results of HLA-mismatched kidney transplantation without
maintenance immunosuppression (IS) in 10 subjects following combined kidney and bone …

Many strategies have been proposed to induce tolerance to transplanted tissue in rodents;
however, few if any have shown equal efficacy when tested in nonhuman primate transplant …

Selective inhibition of T cell costimulation using the B7-specific fusion protein CTLA4-Ig has
been shown to induce long-term allograft survival in rodents. Antibodies preventing the …

Postgrafting cyclosporine (CSP) given for 35 days resulted in establishment of stable
marrow grafts from DLA-identical canine littermates after otherwise suboptimal, but …

Allogeneic bone marrow transplantation (in immunocompetent adults) has always required
cytoreductive treatment of recipients with irradiation or cytotoxic drugs to achieve lasting …

▪ Abstract The increasing shortage of human cadaveric organs for purposes of
transplantation has become the critical limiting factor in the number of transplants performed …