A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs
The equivalence of human induced pluripotent stem cells (hiPSCs) and human embryonic
stem cells (hESCs) remains controversial. Here we use genetically matched hESC and …
stem cells (hESCs) remains controversial. Here we use genetically matched hESC and …
Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies
Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and
hold promise for regenerative medicine. For understanding pluripotency and lineage …
hold promise for regenerative medicine. For understanding pluripotency and lineage …
EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy
S Byrne, L Jansen, JM U-King-Im, A Siddiqui… - Brain, 2016 - academic.oup.com
Vici syndrome is a progressive neurodevelopmental multisystem disorder due to recessive
mutations in the key autophagy gene EPG5. We report genetic, clinical, neuroradiological …
mutations in the key autophagy gene EPG5. We report genetic, clinical, neuroradiological …
[HTML][HTML] Genome-scale CRISPR screens identify human pluripotency-specific genes
Human pluripotent stem cells (hPSCs) generate a variety of disease-relevant cells that can
be used to improve the translation of preclinical research. Despite the potential of hPSCs …
be used to improve the translation of preclinical research. Despite the potential of hPSCs …
Aberrant expression of miR‐218 and miR‐204 in human mesial temporal lobe epilepsy and hippocampal sclerosis—Convergence on axonal guidance
Objective Mesial temporal lobe epilepsy (MTLE) is one of the most common types of the
intractable epilepsies and is most often associated with hippocampal sclerosis (HS), which …
intractable epilepsies and is most often associated with hippocampal sclerosis (HS), which …
Integrated loss-and gain-of-function screens define a core network governing human embryonic stem cell behavior
K Naxerova, B Di Stefano, JL Makofske… - Genes & …, 2021 - genesdev.cshlp.org
Understanding the genetic control of human embryonic stem cell function is foundational for
developmental biology and regenerative medicine. Here we describe an integrated genome …
developmental biology and regenerative medicine. Here we describe an integrated genome …
Toxicological mechanism of individual susceptibility to formaldehyde-induced respiratory effects
Understanding the mechanisms of individual susceptibility to exposure to environmental
pollutants has been a challenge in health risk assessment. Here, an integrated approach …
pollutants has been a challenge in health risk assessment. Here, an integrated approach …
Studying human disease using human neurons
Utilizing patient derived cells has enormous promise for discovering new drugs for diseases
of the nervous system, a goal that has been historically quite challenging. In this review, we …
of the nervous system, a goal that has been historically quite challenging. In this review, we …
Impact of RNA-guided technologies for target identification and deconvolution
M Fennell, Q Xiang, A Hwang, C Chen… - Journal of …, 2014 - journals.sagepub.com
For well over a decade, RNA interference (RNAi) has provided a powerful tool for
investigators to query specific gene targets in an easily modulated loss-of-function setting …
investigators to query specific gene targets in an easily modulated loss-of-function setting …
Variation of DNA methylation on the IRX1/2 genes is responsible for the neural differentiation propensity in human induced pluripotent stem cells
A Sekiya, K Takasawa, Y Arai, S Horike, H Akutsu… - Regenerative …, 2022 - Elsevier
Introduction Human induced pluripotent stem cells (hiPSCs) are useful tools for reproducing
neural development in vitro. However, each hiPSC line has a different ability to differentiate …
neural development in vitro. However, each hiPSC line has a different ability to differentiate …