Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery.
PEI and its derivatives are extensively used in basic research and as reference formulations …

The haemophilias are inherited disorders in which one of the coagulation factors is deficient.
Although deficiencies of factor VIII (haemophilia A) and factor IX (haemophilia B) are well …

The last 10 years have seen substantial progress in the development and application of
nonviral vectors in gene therapy. However, many problems remain to be resolved before …

Abstract Fructose-2, 6-bisphosphate is responsible for mediating glucagon-stimulated
gluconeogenesis in the liver. This discovery has led to the realization that this compound …

RNA interference (RNAi) is one of the most importantly protective phenomena forming from
the process combating against virus. Since its high efficiency for silencing the expression of …

Uridine‐diphosphoglucuronate glucuronosyltransferases (UGTs) are a family of enzymes
that conjugate various endogenous and exogenous compounds with glucuronic acid and …

Abstract The Sleeping Beauty (SB) transposon system, derived from teleost fish sequences,
is extremely effective at delivering DNA to vertebrate genomes, including those of humans …

Enzymes that catalyze the biotransformation of drugs and xenobiotics are generally referred
to as drug‐metabolizing e nzymes (DMEs). DMEs can be classified into two main groups …

This article is an updated report of a symposium held at the June 2000 annual meeting of
the American Society for Pharmacology and Experimental Therapeutics in Boston. The …

Introduction 3. Asialoglycoprotein receptor 3.1. Biology of asialoglycoprotein receptor (ASGP-
R) 3.2. Carbohydrate recognition domain (CRD) 3.3 Internalization of the ligands by ASGP …