Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities.
Developing compounds with heterocycle rings has been one of the trends. The integration of …

Cancer is one of the most common causes of death globally. Despite extensive research
and considerable advances in cancer therapy, the fundamentals of the disease remain …

Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …

This review focuses on one family of the known cAMP receptors, the exchange proteins
directly activated by cAMP (EPACs), also known as the cAMP-regulated guanine nucleotide …

Abstract Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family,
is an important regulator of basic cellular functions (eg, formation and control of cell …

Malignant carcinomas are often characterized by metastasis, the movement of carcinoma
cells from a primary site to colonize distant organs. For metastasis to occur, carcinoma cells …

Rationale: Intercellular tight junctions are crucial for correct regulation of the endothelial
barrier. Their composition and integrity are affected in pathological contexts, such as …

cAMP is a universal second messenger that plays central roles in cardiovascular regulation
influencing gene expression, cell morphology, and function. A crucial step toward a better …

The Ras superfamily of small GTPases are guanine‐nucleotide‐dependent switches
essential for numerous cellular processes. Mutations or dysregulation of these proteins are …

Mechanical allodynia (other pain) is a painful sensation caused by innocuous stimuli like
light touch. Unlike inflammatory hyperalgesia that has a protective role, allodynia has no …