A systematic review and analysis of the use of polygenic scores in pharmacogenomics

D Johnson, MKAP Wilke, SM Lyle… - Clinical …, 2022 - Wiley Online Library
Polygenic scores (PGSs) have emerged as promising tools for complex trait risk prediction.
The application of these scores to pharmacogenomics provides new opportunities to …

A systematic review of polygenic models for predicting drug outcomes

A Siemens, SJ Anderson, SR Rassekh… - Journal of Personalized …, 2022 - mdpi.com
Polygenic models have emerged as promising prediction tools for the prediction of complex
traits. Currently, the majority of polygenic models are developed in the context of predicting …

A combined microRNA and target protein-based panel for predicting the probability and severity of uraemic vascular calcification: a translational study

CT Chao, HY Yeh, YT Tsai, CK Chiang… - Cardiovascular …, 2021 - academic.oup.com
Aims Vascular calcification (VC) increases the future risk of cardiovascular events in uraemic
patients, but effective therapies are still unavailable. Accurate identification of those at risk of …

Recent advances in elucidating the genetic basis of systemic sclerosis

G Villanueva-Martín, J Martín… - Current Opinion in …, 2022 - journals.lww.com
Early diagnosis and clinical management of SSc and SSc-related complications are still
challenging for rheumatologists. The development of predictive models and tools using …

The state of play in tools for predicting immunoglobulin resistance in Kawasaki disease

MMH Guo, HC Kuo - Expert Review of Clinical Immunology, 2023 - Taylor & Francis
Introduction Intravenous immunoglobulin (IVIG) resistance is an independent risk factor for
the development of coronary artery lesions (CAL) in patients with Kawasaki disease (KD) …

Anti-inflammatory treatment of Kawasaki disease: comparison of current guidelines and perspectives

P Buda, J Friedman-Gruszczyńska, J Książyk - Frontiers in Medicine, 2021 - frontiersin.org
Kawasaki disease (KD), an acute, generalized vasculitis, is associated with an increased
risk of coronary heart disease and is the most common cause of acquired heart disease in …

Risk factors of intravenous immunoglobulin resistance in children with Kawasaki disease: a meta-analysis of case-control studies

G Liu, S Wang, Z Du - Frontiers in pediatrics, 2020 - frontiersin.org
Previous studies have shown that children with Kawasaki disease (KD) who fail to respond
to intravenous immunoglobulin (IVIG) therapy are at higher risk of developing coronary …

Vasculitis pathogenesis: can we talk about precision medicine?

S Ozen, ED Batu - Frontiers in Immunology, 2018 - frontiersin.org
Precision medicine is designing the medical care by taking into account the individual
variability for each person. We have tried to address whether the existing data may guide …

[HTML][HTML] Multiple intravenous antibiotics usage is associated with intravenous immunoglobulin resistance in Kawasaki disease

ZM Lee, CL Chu, CH Chu, LS Chang, HC Kuo - Pediatrics & Neonatology, 2022 - Elsevier
Background Kawasaki disease (KD) is a form of systemic vasculitis that primarily affects
children under the age of 5 years old. Antibiotics are often prescribed for KD patients even …

Association between rs12037447, rs146732504, rs151078858, rs55723436, and rs6094136 polymorphisms and Kawasaki Disease in the population of polish …

P Buda, M Chyb, A Smorczewska-Kiljan… - Frontiers in …, 2021 - frontiersin.org
Background: Kawasaki disease (KD) is an acute self-limited febrile vasculitis that mainly
affects young children. Coronary artery involvement is the most serious complication in …