Trypanosoma cruzi is the etiologic agent of Chagas disease, a neglected tropical disease
that affects millions of people mainly in Latin America. To establish a life-long infection, T …

Trypanosoma cruzi infection and Chagas disease remains among the most neglected of the
neglected tropical diseases. Despite this, studies of the immune response to T. cruzi have …

CD8+ T cells are crucial for control of a number of medically important protozoan parasites,
including Trypanosoma cruzi, the agent of human Chagas disease. Yet, in contrast to the …

The question of the cause and the mechanisms of disease in chronic Trypanosoma cruzi
infection continues to attract debate. Chagas disease, characterized by cardiomyopathy …

This study sought to quantify CD8+ T cell responses to Trypanosoma cruzi and to identify
potential links between these responses and the severity of disease in humans. In the …

Chagas disease is a leading cause of heart disease affecting approximately 10 million
people in Latin America and elsewhere worldwide. The two major drugs available for the …

The neglected tropical diseases represent a group of parasitic and bacterial diseases,
occurring primarily in rural areas or impoverished urban areas of developing countries …

CD8+ T cells are crucial to the control of Trypanosoma cruzi infection and probably act via
multiple mechanisms, the most important being the production of interferon‐γ (IFN‐γ). In the …

The intracellular protozoan parasite Trypanosoma cruzi is the etiological agent of Chagas
disease. We have recently identified a T. cruzi-released protein related to thiol-disulfide …

Protozoa are responsible for considerable morbidity and mortality in domestic and
companion animals. Preventing infection may involve deliberate exposure to virulent or …