High-throughput methods in the discovery and study of biomaterials and materiobiology

L Yang, S Pijuan-Galito, HS Rho, AS Vasilevich… - Chemical …, 2021 - ACS Publications
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

[HTML][HTML] A 3D biofabricated cutaneous squamous cell carcinoma tissue model with multi-channel confocal microscopy imaging biomarkers to quantify antitumor effects …

JR Browning, P Derr, K Derr, N Doudican, S Michael… - Oncotarget, 2020 - ncbi.nlm.nih.gov
Cutaneous squamous cell carcinoma (cSCC) causes approximately 10,000 deaths annually
in the US Current therapies are largely ineffective against metastatic and locally advanced …

Usability of deep learning pipelines for 3D nuclei identification with Stardist and Cellpose

G Kleinberg, S Wang, E Comellas, JR Monaghan… - Cells & Development, 2022 - Elsevier
Segmentation of 3D images to identify cells and their molecular outputs can be difficult and
tedious. Machine learning algorithms provide a promising alternative to manual analysis as …

The effects of the combination of mesenchymal stromal cells and nanofiber-hydrogel composite on repair of the contused spinal cord

AE Haggerty, I Maldonado-Lasunción, Y Nitobe… - Cells, 2022 - mdpi.com
A bone marrow-derived mesenchymal stromal cell (MSC) transplant and a bioengineered
nanofiber-hydrogel composite (NHC) have been shown to stimulate nervous tissue repair in …

Characteristics and antitumor activity of polysorbate 80 curcumin micelles preparation by cloud point cooling

G Wang, S Sukumar - Journal of Drug Delivery Science and Technology, 2020 - Elsevier
Curcumin is a natural bioactive compound with known potential for cancer treatment and
prevention. However, a major barrier for clinical application is its poor solubility and …

Mesenchymal folliculin is required for alveolar development: implications for cystic lung disease in Birt-Hogg-Dubé syndrome

L Chu, Y Luo, H Chen, Q Miao, L Wang, R Moats… - Thorax, 2020 - thorax.bmj.com
Background Pulmonary cysts and spontaneous pneumothorax are presented in most
patients with Birt-Hogg-Dubé (BHD) syndrome, which is caused by loss of function mutations …

DEFiNE: a method for enhancement and quantification of fluorescently labeled axons

JM Powell, NW Plummer, EL Scappini… - Frontiers in …, 2019 - frontiersin.org
Visualization and quantification of fluorescently labeled axonal fibers are widely employed
in studies of neuronal connectivity in the brain. However, accurate analysis of axon density …

Printed capacitive immunoassay for detecting SARS-CoV-2 viral particles

M Tursunniyaz, J Andrews - IEEE Sensors Journal, 2022 - ieeexplore.ieee.org
The key to fight against a global pandemic such as COVID-19 is to have low-cost, reliable,
and fast-response diagnostic tools. Electronic biosensors are preferred because of their …

Skin Whole‐Mount Immunofluorescent Staining Protocol, 3D Visualization, and Spatial Image Analysis

AJ Schmidt, GD Wright, F Ronchese… - Current Protocols, 2023 - Wiley Online Library
The use of polychromatic immunofluorescent staining on whole‐mount skin enables cell
type characterization and aids in the delineation of the physiological and immunological …

Prosthetic mechanobiology: how prosthesis-related loading can influence skeletal muscle health

M Sargent - 2023 - stax.strath.ac.uk
The soft tissue of the residual limb in transtibial prosthetic users encounters unique
biomechanical challenges. Although not intended to tolerate high loads and deformation, it …