Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

For a long time, scientists have tried to describe disorders just by genetic or environmental
factors. However, the role of epigenetics in human diseases has been considered from a …

Only relatively recently has it become clear that mammalian genomes encode tens of
thousands of long non-coding RNAs (lncRNAs). A striking 40% of these are expressed …

Cancer is a disease of aberrant gene expression. While the genetic causes of cancer have
been intensively studied, it is becoming evident that a large proportion of cancer …

Transcription, translation and subsequent protein modification represent the transfer of
genetic information from the archival copy of DNA to the short-lived messenger RNA, usually …

Expression of the INK4b/ARF/INK4a tumor suppressor locus in normal and cancerous cell
growth is controlled by methylation of histone H3 at lysine 27 (H3K27me) as directed by the …

There is now compelling evidence that the complexity of higher organisms correlates with
the relative amount of non-coding RNA rather than the number of protein-coding genes …

Cancer is one of the leading cause of death in the world with the prevalence of> 10 million
mortalities annually. Current cancer treatments include surgical intervention, radiation, and …

Recent RNA sequencing studies have revealed that most of the human genome is
transcribed, but very little of the total transcriptomes has the ability to encode proteins. Long …

Pervasive transcription occurs in the human genome to generate thousands of RNA
transcripts, and accumulating evidence suggested that the RNA molecules, without protein …