Hepatitis C virus infection
MP Manns, M Buti, ED Gane, JM Pawlotsky… - Nature reviews Disease …, 2017 - nature.com
Hepatitis C virus (HCV) is a hepatotropic RNA virus that causes progressive liver damage,
which might result in liver cirrhosis and hepatocellular carcinoma. Globally, between 64 and …
which might result in liver cirrhosis and hepatocellular carcinoma. Globally, between 64 and …
Pharmacokinetic, pharmacodynamic, and drug-interaction profile of the hepatitis C virus NS5B polymerase inhibitor sofosbuvir
BJ Kirby, WT Symonds, BP Kearney… - Clinical pharmacokinetics, 2015 - Springer
Sofosbuvir (SOVALDI®), a potent, once-daily, orally administered nucleotide analog prodrug
inhibitor of the hepatitis C virus (HCV) NS5B polymerase is approved in the USA, EU …
inhibitor of the hepatitis C virus (HCV) NS5B polymerase is approved in the USA, EU …
Pharmacokinetics, safety and efficacy of a full dose sofosbuvir-based regimen given daily in hemodialysis patients with chronic hepatitis C
A Desnoyer, D Pospai, MP Lê, A Gervais… - Journal of …, 2016 - Elsevier
Background & Aims Hepatitis C virus (HCV) infection is an independent risk factor for
chronic kidney disease and leads to faster liver disease progression in patients requiring …
chronic kidney disease and leads to faster liver disease progression in patients requiring …
Safety, efficacy and tolerability of half-dose sofosbuvir plus simeprevir in treatment of Hepatitis C in patients with end stage renal disease
BK Ram, C Frank, P Adam, L Cynthia… - Journal of …, 2015 - journal-of-hepatology.eu
Methods Of the 15 patients, 12 (80%) were on dialysis (11 hemodialysis, one peritoneal)
and the rest had a GFR between eight and 15 ml/min. The University of Miami IRB approved …
and the rest had a GFR between eight and 15 ml/min. The University of Miami IRB approved …
Hepatitis C virus and the kidney
S Pol, L Parlati, M Jadoul - Nature Reviews Nephrology, 2019 - nature.com
Hepatitis C virus (HCV) infection is more prevalent and is associated with higher mortality in
patients receiving dialysis and in kidney transplant recipients than in the general population …
patients receiving dialysis and in kidney transplant recipients than in the general population …
Viral hepatitis C therapy: pharmacokinetic and pharmacodynamic considerations: a 2019 update
EJ Smolders, AME Jansen, PGJ Ter Horst… - Clinical …, 2019 - Springer
It has been estimated by the World Health Organization (WHO) that over 71 million people
were infected with the hepatitis C virus (HCV) in 2015. Since then, a number of highly …
were infected with the hepatitis C virus (HCV) in 2015. Since then, a number of highly …
[PDF][PDF] KDIGO 2018 clinical practice guideline for the prevention, diagnosis, evaluation, and treatment of hepatitis C in chronic kidney disease
KDIGO Hepatitis C Work Group - Kidney International …, 2018 - discovery.ucl.ac.uk
The development and publication of this guideline were supported by KDIGO. The opinions
or views expressed in this professional education supplement are those of the authors and …
or views expressed in this professional education supplement are those of the authors and …
Managing drug–drug interactions with new direct‐acting antiviral agents in chronic hepatitis C
S Talavera Pons, A Boyer, G Lamblin… - British journal of …, 2017 - Wiley Online Library
Several direct‐acting antiviral agents (DAAs) have marketing authorization in Europe and in
the USA and have changed the landscape of hepatitis C treatment: each DAA has its own …
the USA and have changed the landscape of hepatitis C treatment: each DAA has its own …
DAA‐based antiviral treatment of patients with chronic hepatitis C in the pre‐and postkidney transplantation setting
S Beinhardt, R Al Zoairy, P Ferenci… - Transplant …, 2016 - Wiley Online Library
DAA‐based regimens for chronic hepatitis C infection encourage treatment of “difficult‐to‐
treat” cohorts. This study investigated efficacy and safety of DAA‐based regimens in HCV …
treat” cohorts. This study investigated efficacy and safety of DAA‐based regimens in HCV …
Pharmacokinetics, efficacy, and safety of hepatitis C virus drugs in patients with liver and/or renal impairment
EJ Smolders, CTMM de Kanter, B van Hoek, JE Arends… - Drug safety, 2016 - Springer
Hepatitis C virus (HCV)-infected patients often suffer from liver cirrhosis, which can be
complicated by renal impairment. Therefore, in this review we describe the treatment …
complicated by renal impairment. Therefore, in this review we describe the treatment …