Certain morphological, physiological and molecular characteristics are shared by all
neurons. However, despite these similarities, neurons constitute the most diverse cell …

The procedure of neurogenesis has made numerous achievements in the past decades,
during which various molecular biomarkers have been emerging and have been broadly …

Gene expression is central to the genotype-phenotype relationship in all organisms, and it is
an important component of the genetic basis for evolutionary change in diverse aspects of …

The oligodendrocyte lineage genes Olig1 and Olig2 encode related bHLH proteins that are
coexpressed in neural progenitors. Targeted disruption of these two genes sheds light on …

OLIG1 and OLIG2 are basic-helix-loop-helix (bHLH) transcription factors expressed in the
pMN domain of the spinal cord, which sequentially generates motoneurons and …

Cell state changes are associated with proteome remodeling to serve newly emergent cell
functions. Here, we show that NGN2-driven conversion of human embryonic stem cells to …

Abstract Development of endocrine cells in the endoderm involves Atonal and
Achaete/Scute-related basic helix-loop-helix (bHLH) proteins. These proteins also serve as …

Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to
regulate plant growth and development. We showed previously that a novel protein, BES1 …

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Most common genetic risk variants associated with neuropsychiatric disease are noncoding
and are thought to exert their effects by disrupting the function of cis regulatory elements …