The nanoparticle biomolecule corona: lessons learned–challenge accepted?

D Docter, D Westmeier, M Markiewicz… - Chemical Society …, 2015 - pubs.rsc.org
Besides the wide use of engineered nanomaterials (NMs) in technical products, their
applications are not only increasing in biotechnology and biomedicine, but also in the …

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

CD Walkey, WCW Chan - Chemical Society Reviews, 2012 - pubs.rsc.org
Nanomaterials hold promise as multifunctional diagnostic and therapeutic agents. However,
the effective application of nanomaterials is hampered by limited understanding and control …

Chemical basis of interactions between engineered nanoparticles and biological systems

Q Mu, G Jiang, L Chen, H Zhou, D Fourches… - Chemical …, 2014 - ACS Publications
As defined by the European Commission, a nanomaterial is a natural, an incidental, or a
manufactured material containing particles in an unbound state or as an aggregate or …

Protein− nanoparticle interactions: opportunities and challenges

M Mahmoudi, I Lynch, MR Ejtehadi… - Chemical …, 2011 - ACS Publications
In recent years, the fabrication of nanomaterials and exploration of their properties have
attracted the attention of all branches of science, such as physics, chemistry, biology, and …

The evolution of the protein corona around nanoparticles: a test study

M Lundqvist, J Stigler, T Cedervall, T Berggard… - ACS …, 2011 - ACS Publications
The importance of the protein corona formed around nanoparticles upon entering a
biological fluid has recently been highlighted. This corona is, when sufficiently long-lived …

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

P Aggarwal, JB Hall, CB McLeland… - Advanced drug delivery …, 2009 - Elsevier
Proteins bind the surfaces of nanoparticles, and biological materials in general, immediately
upon introduction of the materials into a physiological environment. The further biological …

Polysaccharides-based nanoparticles as drug delivery systems

Z Liu, Y Jiao, Y Wang, C Zhou, Z Zhang - Advanced drug delivery reviews, 2008 - Elsevier
Natural polysaccharides, due to their outstanding merits, have received more and more
attention in the field of drug delivery systems. In particular, polysaccharides seem to be the …

Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticles

T Cedervall, I Lynch, S Lindman… - Proceedings of the …, 2007 - National Acad Sciences
Due to their small size, nanoparticles have distinct properties compared with the bulk form of
the same materials. These properties are rapidly revolutionizing many areas of medicine …

Nanoparticle characterization: state of the art, challenges, and emerging technologies

EJ Cho, H Holback, KC Liu… - Molecular …, 2013 - ACS Publications
Nanoparticles have received enormous attention as a promising tool to enhance target-
specific drug delivery and diagnosis. Various in vitro and in vivo techniques are used to …

Methods for the preparation and manufacture of polymeric nanoparticles

C Vauthier, K Bouchemal - Pharmaceutical research, 2009 - Springer
This review summarizes the different methods of preparation of polymer nanoparticles
including nanospheres and nanocapsules. The first part summarizes the basic principle of …