The contributions by blood cells to pathological venous thrombosis were only recently
appreciated. Both platelets and neutrophils are now recognized as crucial for thrombus …

Neutrophils have long been known as innate immune cells that phagocytose and kill
pathogens and mount inflammatory responses protecting the host from infection. In the past …

Neutrophils play a major role in cancer biology and both pro-and antitumoral functions of
tumor-infiltrating neutrophils have been described. We have shown that tumors, by releasing …

Emerging evidence shows a broad spectrum of biological functions of tissue factor (TF). TF
classical role in initiating the extrinsic blood coagulation and its direct thrombotic action in …

Abstract Store-operated Ca 2+ entry (SOCE) encoded by Orai1 proteins is a ubiquitous Ca
2+-selective conductance involved in cellular proliferation and migration. We recently …

Thrombin-mediated proteolysis is a major determinant of metastasis, but is not universally
important for primary tumor growth. Here, we report that colorectal adenocarcinoma …

Thrombin is the protease involved in blood coagulation. Its deregulation can lead to
hemostatic abnormalities, which range from subtle subclinical to serious life-threatening …

The high occurrence of cancer-associated thrombosis is associated with elevated thrombin
generation. Tumour cells increase the potential for thrombin generation both directly …

Prostate cancer (PCa) is considered to be a frequently diagnosed cancer in males with high
mortality worldwide, but the molecular mechanism responsible for prostate tumorigenesis …

Inhibition of coagulation greatly limits cancer metastasis in many experimental models.
Cancer cells trigger coagulation, through expression of tissue factor or P‐selectin ligands …