The mammalian kidney develops through reciprocal interactions between the ureteric bud
and the metanephric mesenchyme to give rise to the entire collecting system and the …

Abstract In late 2004, an International Consortium of research groups were charged with the
task of producing a high-quality molecular anatomy of the developing mammalian urogenital …

Cataloguing gene expression during development of the genitourinary tract will increase our
understanding not only of this process but also of congenital defects and disease affecting …

Ureteric contractions propel foetal urine from the kidney to the urinary bladder. Here, we
show that mouse ureteric smooth muscle cell (SMC) precursors express the transcription …

After the basic shape of the mammalian ureter is established, its epithelia mature and a coat
of smooth muscle cells differentiate around nascent urothelia. The ureter actively propels …

Lymphangiogenesis is the critical processof forming new lymphatic vessels
underphysiological and pathological conditions andinvolves both molecular and …

Bone morphogenetic protein (BMP) signaling pathway plays important roles in urinary tract
development although the detailed regulation of its activity in this process remains unclear …

Several members of the transforming growth factor-β (TGF-β) superfamily play key roles in
kidney development, either directly or indirectly regulating nephron number. Although low …

The E11. 5 mouse metanephros is comprised of a T-stage ureteric epithelial tubule sub-
divided into tip and trunk cells surrounded by metanephric mesenchyme (MM). Tip cells are …

The mature nephron forms from a simple epithelial vesicle into an elaborate structure with
distinct regions of specialized physiological function. The molecular components driving the …