Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection

Y Persidsky, HE Gendelman - Journal of Leucocyte Biology, 2003 - academic.oup.com
Human immunodeficiency virus type 1 (HIV-1)-associated dementia is a neuroinflammatory
brain disorder that is fueled by viral infection and immune activation of brain mononuclear …

Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy

AJ Gill, DL Kolson - Critical Reviews™ in Immunology, 2013 - dl.begellhouse.com
The persistence of chronic immune activation and oxidative stress in human
immunodeficiency virus (HIV)-infected, antiretroviral drug-treated individuals are major …

FGF2 gene transfer restores hippocampal functions in mouse models of Alzheimer's disease and has therapeutic implications for neurocognitive disorders

T Kiyota, KL Ingraham, MT Jacobsen… - Proceedings of the …, 2011 - National Acad Sciences
The adult hippocampus plays a central role in memory formation, synaptic plasticity, and
neurogenesis. The subgranular zone of the dentate gyrus contains neural progenitor cells …

N-(Pivaloyloxy)alkoxy-carbonyl Prodrugs of the Glutamine Antagonist 6-Diazo-5-oxo-l-norleucine (DON) as a Potential Treatment for HIV Associated Neurocognitive …

MT Nedelcovych, L Tenora, BH Kim… - Journal of medicinal …, 2017 - ACS Publications
Aberrant excitatory neurotransmission associated with overproduction of glutamate has
been implicated in the development of HIV-associated neurocognitive disorders (HAND) …

Altered hippocampal-prefrontal activation in HIV patients during episodic memory encoding

JMB Castelo, SJ Sherman, MG Courtney, RJ Melrose… - Neurology, 2006 - AAN Enterprises
Objective: To investigate the integrity of hippocampal-prefrontal circuitry during episodic
encoding in patients with HIV. Methods: Functional MRI was used to observe changes in …

Glutamate metabolism and HIV-associated neurocognitive disorders

FJ Vázquez-Santiago, RJ Noel, JT Porter… - Journal of …, 2014 - Springer
HIV-1 infection can lead to neurocognitive impairment collectively known as HIV-associated
neurocognitive disorders (HAND). Although combined antiretroviral treatment (cART) has …

Potential pharmacological approaches for the treatment of HIV-1 associated neurocognitive disorders

A Omeragic, O Kayode, MT Hoque… - Fluids and Barriers of the …, 2020 - Springer
HIV associated neurocognitive disorders (HAND) are the spectrum of cognitive impairments
present in patients infected with human immunodeficiency virus type 1 (HIV-1). The number …

[PDF][PDF] Virus-induced neuronal dysfunction and degeneration

SH Berth, PL Leopold, GN Morfini - Front Biosci, 2009 - article.imrpress.com
Pathologies of the nervous system caused by viral invasion 2.1. Brain pathologies 2.2.
Spinal cord pathologies 2.3. Pathologies of the peripheral nervous system 2.4. Acute viral …

Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis

E Masliah, ES Roberts, D Langford, I Everall… - Journal of …, 2004 - Elsevier
The neurodegenerative process in HIV encephalitis (HIVE) is associated with extensive
damage to the dendritic and synaptic structure that often leads to cognitive impairment …

Rodent models for HIV-associated neurocognitive disorders

S Gorantla, L Poluektova, HE Gendelman - Trends in neurosciences, 2012 - cell.com
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) reflect
the spectrum of neural impairments seen during chronic viral infection. Current research …