RNA and condensates: Disease implications and therapeutic opportunities
Biomolecular condensates are dynamic membraneless organelles that compartmentalize
proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert …
proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert …
Therapeutic targeting of RNA for neurological and neuromuscular disease
JL Bubenik, MM Scotti, MS Swanson - Genes & Development, 2024 - genesdev.cshlp.org
Neurological and neuromuscular diseases resulting from familial, sporadic, or de novo
mutations have devasting personal, familial, and societal impacts. As the initial product of …
mutations have devasting personal, familial, and societal impacts. As the initial product of …
Emotional dysregulation and post-traumatic stress symptoms: which interaction in adolescents and young adults? A systematic review
L Conti, S Fantasia, M Violi, V Dell'Oste, V Pedrinelli… - Brain sciences, 2023 - mdpi.com
Emotional dysregulation (ED) has recently been conceptualized as a transnosographic
entity in major mental disorders, and increasing evidence has suggested association …
entity in major mental disorders, and increasing evidence has suggested association …
Identification of genetic modifiers of Huntington′ s disease somatic CAG repeat instability by in vivo CRISPR-Cas9 genome editing
R Mouro Pinto, R Murtha, A Azevedo, C Douglas… - bioRxiv, 2024 - biorxiv.org
Huntington′ s disease (HD), one of over 50 inherited repeat expansion disorders
(Depienne and Mandel, 2021), is a dominantly-inherited neurodegenerative disease caused …
(Depienne and Mandel, 2021), is a dominantly-inherited neurodegenerative disease caused …
Genetic modifiers of somatic expansion and clinical phenotypes in Huntington's disease reveal shared and tissue-specific effects
Genetic Modifiers of Huntington's Disease (GeM-HD) … - bioRxiv, 2024 - biorxiv.org
Huntington's disease (HD), due to expansion of a CAG repeat in HTT, is representative of a
growing number of disorders involving somatically unstable short tandem repeats. We find …
growing number of disorders involving somatically unstable short tandem repeats. We find …
[图书][B] Potential mediators of sexual assault risk recognition among women with histories of childhood sexual abuse
SD Gold - 2008 - search.proquest.com
This study examined the roles that several variables play in risk recognition among adult
women with and without histories of childhood sexual abuse (CSA). These variables …
women with and without histories of childhood sexual abuse (CSA). These variables …