The road to elimination: current state of schistosomiasis research and progress towards the end game
P Ogongo, RK Nyakundi, GK Chege… - Frontiers in …, 2022 - frontiersin.org
The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of
schistosomiasis as a public health problem. To date, control strategies have focused on …
schistosomiasis as a public health problem. To date, control strategies have focused on …
Vaccines for human schistosomiasis: recent progress, new developments and future prospects
AJ Molehin, DP McManus, H You - International Journal of Molecular …, 2022 - mdpi.com
Schistosomiasis, caused by human trematode blood flukes (schistosomes), remains one of
the most prevalent and serious of the neglected tropical parasitic diseases. Currently …
the most prevalent and serious of the neglected tropical parasitic diseases. Currently …
Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis
A Saha, T Chakraborty, J Rahimikollu, H Xiao… - Science Translational …, 2024 - science.org
Schistosomiasis, a highly prevalent parasitic disease, affects more than 200 million people
worldwide. Current diagnostics based on parasite egg detection in stool detect infection only …
worldwide. Current diagnostics based on parasite egg detection in stool detect infection only …
Fifty years of the schistosome tegument: discoveries, controversies, and outstanding questions
The unique multilaminate appearance of the tegument surface of schistosomes was first
described in 1973, in one of the earliest volumes of the International Journal for …
described in 1973, in one of the earliest volumes of the International Journal for …
Schistosoma mansoni vaccine candidates identified by unbiased phage display screening in self-cured rhesus macaques
Schistosomiasis, a challenging neglected tropical disease, affects millions of people
worldwide. Developing a prophylactic vaccine against Schistosoma mansoni has been …
worldwide. Developing a prophylactic vaccine against Schistosoma mansoni has been …
Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge
The rhesus macaque provides a unique model of acquired immunity against schistosomes,
which afflict> 200 million people worldwide. By monitoring bloodstream levels of parasite …
which afflict> 200 million people worldwide. By monitoring bloodstream levels of parasite …
Models of Protective Immunity against Schistosomes: Implications for Vaccine Development
RA Wilson - Pathogens, 2023 - mdpi.com
After many decades of research, a schistosome vaccine still looks to be a distant prospect.
These helminths can live in the human bloodstream for years, even decades, surrounded by …
These helminths can live in the human bloodstream for years, even decades, surrounded by …
Antigenic epitope targets of rhesus macaques self-curing from Schistosoma mansoni infection
GM Vance, MI Khouri, APS Neto, S James… - Frontiers in …, 2024 - frontiersin.org
The self-cure of rhesus macaques from a schistosome infection and their subsequent strong
immunity to a cercarial challenge should provide novel insights into the way these parasites …
immunity to a cercarial challenge should provide novel insights into the way these parasites …
Identification of antigenic linear peptides in the soil-transmitted helminth and Schistosoma mansoni proteome
J Vlaminck, O Lagatie, D Dana… - PLoS Neglected …, 2021 - journals.plos.org
The scientific community identified non stool-based biomarkers as the way forward to
support soil-transmitted helminth (STH; Ascaris lumbricoides, Trichuris trichiura and the …
support soil-transmitted helminth (STH; Ascaris lumbricoides, Trichuris trichiura and the …
Schistosome proteomics: updates and clinical implications
W Castro-Borges, RA Wilson - Expert Review of Proteomics, 2022 - Taylor & Francis
Introduction Schistosomes are long-lived blood dwelling helminth parasites using intricate
mechanisms to invade, mature, and reproduce inside their vertebrate hosts, whilst …
mechanisms to invade, mature, and reproduce inside their vertebrate hosts, whilst …