The road to elimination: current state of schistosomiasis research and progress towards the end game

P Ogongo, RK Nyakundi, GK Chege… - Frontiers in …, 2022 - frontiersin.org
The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of
schistosomiasis as a public health problem. To date, control strategies have focused on …

Vaccines for human schistosomiasis: recent progress, new developments and future prospects

AJ Molehin, DP McManus, H You - International Journal of Molecular …, 2022 - mdpi.com
Schistosomiasis, caused by human trematode blood flukes (schistosomes), remains one of
the most prevalent and serious of the neglected tropical parasitic diseases. Currently …

Deep humoral profiling coupled to interpretable machine learning unveils diagnostic markers and pathophysiology of schistosomiasis

A Saha, T Chakraborty, J Rahimikollu, H Xiao… - Science Translational …, 2024 - science.org
Schistosomiasis, a highly prevalent parasitic disease, affects more than 200 million people
worldwide. Current diagnostics based on parasite egg detection in stool detect infection only …

Fifty years of the schistosome tegument: discoveries, controversies, and outstanding questions

RA Wilson, MK Jones - International Journal for Parasitology, 2021 - Elsevier
The unique multilaminate appearance of the tegument surface of schistosomes was first
described in 1973, in one of the earliest volumes of the International Journal for …

Schistosoma mansoni vaccine candidates identified by unbiased phage display screening in self-cured rhesus macaques

D Woellner-Santos, AC Tahira, JVM Malvezzi, V Mesel… - npj Vaccines, 2024 - nature.com
Schistosomiasis, a challenging neglected tropical disease, affects millions of people
worldwide. Developing a prophylactic vaccine against Schistosoma mansoni has been …

Rhesus macaques self-curing from a schistosome infection can display complete immunity to challenge

MS Amaral, DW Santos, ASA Pereira, AC Tahira… - Nature …, 2021 - nature.com
The rhesus macaque provides a unique model of acquired immunity against schistosomes,
which afflict> 200 million people worldwide. By monitoring bloodstream levels of parasite …

Models of Protective Immunity against Schistosomes: Implications for Vaccine Development

RA Wilson - Pathogens, 2023 - mdpi.com
After many decades of research, a schistosome vaccine still looks to be a distant prospect.
These helminths can live in the human bloodstream for years, even decades, surrounded by …

Antigenic epitope targets of rhesus macaques self-curing from Schistosoma mansoni infection

GM Vance, MI Khouri, APS Neto, S James… - Frontiers in …, 2024 - frontiersin.org
The self-cure of rhesus macaques from a schistosome infection and their subsequent strong
immunity to a cercarial challenge should provide novel insights into the way these parasites …

Identification of antigenic linear peptides in the soil-transmitted helminth and Schistosoma mansoni proteome

J Vlaminck, O Lagatie, D Dana… - PLoS Neglected …, 2021 - journals.plos.org
The scientific community identified non stool-based biomarkers as the way forward to
support soil-transmitted helminth (STH; Ascaris lumbricoides, Trichuris trichiura and the …

Schistosome proteomics: updates and clinical implications

W Castro-Borges, RA Wilson - Expert Review of Proteomics, 2022 - Taylor & Francis
Introduction Schistosomes are long-lived blood dwelling helminth parasites using intricate
mechanisms to invade, mature, and reproduce inside their vertebrate hosts, whilst …