After more than a century from its discovery, valproic acid (VPA) still represents one of the
most efficient antiepileptic drugs (AEDs). Pre and post-synaptic effects of VPA depend on a …

Epigenetic mechanisms—including DNA methylation, histone post-translational
modifications and changes in nucleosome positioning—regulate gene expression, cellular …

Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in
histones and other proteins and in regulating fundamental cellular activities such as …

Neuroprotection and brain repair in patients after acute brain damage are still major
unfulfilled medical needs. Pharmacological treatments are either ineffective or confounded …

Gelsolin, an actin-depolymerizing protein expressed both in extracellular fluids and in the
cytoplasm of a majority of human cells, has been recently implicated in a variety of both …

Many of the best-studied actin regulatory proteins use non-covalent means to modulate the
properties of actin. Yet, actin is also susceptible to covalent modifications of its amino acids …

Abstract Gelsolin, a Ca2+‐regulated actin filament severing, capping, and nucleating
protein, is an ubiquitous, multifunctional regulator of cell structure and metabolism. More …

Activation of microglia is a common denominator and a pathophysiological hallmark of the
central nervous system (CNS) disorders. Damage or CNS disorders can trigger inflammatory …

Interest in histone deacetylase (HDAC)-based therapeutics as a potential treatment for
stroke has grown dramatically. The neuroprotection of HDAC inhibition may involve multiple …

Epigenetic regulation of neuronal signalling through histone acetylation dictates
transcription programs that govern neuronal memory, plasticity and learning paradigms …