Advances in neuroimaging have enabled greater understanding of the progression of
cerebral degenerative processes associated with ageing‐related dementias. Leukoaraiosis …

Mind how you go: The current strategies for the development of therapies for Alzheimer's
disease are very diverse. Particular attention is given to the search for inhibitors (see picture …

Importance The extent to which large-caliber axonal degeneration contributes to Alzheimer
disease (AD) progression is unknown. Cerebrospinal fluid (CSF) neurofilament light (NFL) …

Abstract The Alzheimer's Disease Neuroimaging Initiative (ADNI) recently added diffusion
tensor imaging (DTI), among several other new imaging modalities, in an effort to identify …

The purpose of this paper is to establish single-participant white matter atlases based on
diffusion tensor imaging. As one of the applications of the atlas, automated brain …

The amyloid hypothesis (AH) of Alzheimer's disease (AD) posits that the fundamental cause
of AD is the accumulation of the peptide amyloid beta (Aβ) in the brain. This hypothesis has …

Oligodendrocytes (OLs) are mature glial cells that myelinate axons in the brain and spinal
cord. As such, they are integral to functional and efficient neuronal signaling. The embryonic …

Alzheimer's disease is the commonest cause of dementia in the elderly, but its pathological
determinants are still debated. Amyloid-β plaques and neurofibrillary tangles have been …

White matter hyperintensities as seen on brain T 2-weighted magnetic resonance imaging
are associated with varying degrees of cognitive dysfunction in stroke, cerebral small vessel …

The aim of this study was to characterize myelin loss as one of the features of white matter
abnormalities across three common dementing disorders. We evaluated post-mortem brain …