The multifaceted role of aquaporin-9 in health and its potential as a clinical biomarker

IV da Silva, S Garra, G Calamita, G Soveral - Biomolecules, 2022 - mdpi.com
Aquaporins (AQPs) are transmembrane channels essential for water, energy, and redox
homeostasis, with proven involvement in a variety of pathophysiological conditions such as …

Aquaporins: New players in breast cancer progression and treatment response

V Charlestin, D Fulkerson, CE Arias Matus… - Frontiers in …, 2022 - frontiersin.org
Aquaporins (AQPs) are a family of small transmembrane proteins that selectively transport
water and other small molecules and ions following an osmotic gradient across cell plasma …

Aquaglyceroporins: drug targets for metabolic diseases?

G Calamita, J Perret, C Delporte - Frontiers in physiology, 2018 - frontiersin.org
Aquaporins (AQPs) are a family of transmembrane channel proteins facilitating the transport
of water, small solutes, and gasses across biological membranes. AQPs are expressed in all …

AQP9 is a prognostic factor for kidney cancer and a promising indicator for M2 TAM polarization and CD8+ T-cell recruitment

J Jing, J Sun, Y Wu, N Zhang, C Liu, S Chen… - Frontiers in …, 2021 - frontiersin.org
Background It is undeniable that the tumor microenvironment (TME) plays an indispensable
role in the progression of kidney renal clear cell carcinoma (KIRC). However, the precise …

[HTML][HTML] AQP9 transports lactate in tumor-associated macrophages to stimulate an M2-like polarization that promotes colon cancer progression

Y Shi, M Yasui, M Hara-Chikuma - Biochemistry and Biophysics Reports, 2022 - Elsevier
Macrophages play a major role in the immune defense against pathogenic factors; however,
they can lead to tumor exacerbation and metastasis, as the tumor microenvironment (TME) …

[HTML][HTML] Arsenic metabolites; selenium; and AS3MT, MTHFR, AQP4, AQP9, SELENOP, INMT, and MT2A polymorphisms in Croatian-Slovenian population from PHIME …

A Stajnko, Z Šlejkovec, D Mazej, A France-Štiglic… - Environmental …, 2019 - Elsevier
The relationships between inorganic arsenic (iAs) metabolism, selenium (Se) status, and
genetic polymorphisms of various genes, commonly studied in populations exposed to high …

Positively selected modifications in the pore of TbAQP2 allow pentamidine to enter Trypanosoma brucei

AH Alghamdi, JC Munday, GD Campagnaro, D Gurvic… - Elife, 2020 - elifesciences.org
Mutations in the Trypanosoma brucei aquaporin AQP2 are associated with resistance to
pentamidine and melarsoprol. We show that TbAQP2 but not TbAQP3 was positively …

Aquaporins display a diversity in their substrates

R Sachdeva, P Priyadarshini, S Gupta - The Journal of membrane biology, 2023 - Springer
Aquaporins constitute a family of transmembrane proteins that function to transport water
and other small solutes across the cell membrane. Aquaporins family members are found in …

Integrated multiomics analysis reveals changes in liver physiological function in Aqp9 gene knockout mice

Q Cheng, J Zhang, H Ding, Z Wang, J Fang… - International Journal of …, 2023 - Elsevier
Abstract Aquaporin 9 (AQP9) is the main channel by which blood glycerol enters the liver,
where it plays key roles in osmotic pressure regulation and energy metabolism. Previous …

[HTML][HTML] Differential expressions of aquaporin subtypes in female reproductive tract of mice

JW Im, CY Lee, DH Kim, HR Bae - Development & Reproduction, 2020 - ncbi.nlm.nih.gov
Although many aquaporin (AQP) transcripts have been demonstrated to express in the
female reproductive tract, the defined localizations and functions of AQP subtype proteins …