The vast interindividual clinical variability observed in any microbial infection—ranging from
silent infection to lethal disease—is increasingly being explained by human genetic and …

Silicosis is an ancient and potentially fatal pneumoconiosis caused by exposure to
respirable crystalline silica. Silicosis is historically a disease of miners; however, failure to …

Objective Systemic juvenile idiopathic arthritis (JIA) is associated with a recently recognized,
albeit poorly defined and characterized, lung disease (LD). The objective of this study was to …

Lung lipid metabolism participates both in infant and adult pulmonary disease. The lung is
composed by multiple cell types with specialized functions and coordinately acting to meet …

Alveolar macrophages (AM) are critical for defense against bacterial and fungal infections.
However, a definitive role of AM in viral infections remains unclear. We here report that AM …

Bone-marrow transplantation is an effective cell therapy but requires myeloablation, which
increases infection risk and mortality. Recent lineage-tracing studies documenting that …

In acquired pulmonary alveolar proteinosis, lipids and proteins accumulate within the alveoli
because alveolar macrophages cannot catabolize surfactants. Surprisingly, alveolar …

Objective To investigate the characteristics and risk factors of a novel parenchymal lung
disease (LD), increasingly detected in systemic juvenile idiopathic arthritis (sJIA). Methods In …

Granulocyte macrophage‐colony stimulating factor (GM‐CSF) is a hematopoietic growth
factor, which stimulates the proliferation of granulocytes and macrophages from bone …

Rationale: Acquired pulmonary alveolar proteinosis (PAP) is a syndrome characterized by
pulmonary surfactant accumulation occurring in association with granulocyte/macrophage …