Breast cancer is the most common noncutaneous malignancy and the second most lethal
form of cancer among women in the United States. It currently affects more than one in ten …

Germline alterations in many genes coding for proteins regulating DNA repair and DNA
damage response (DDR) to DNA double-strand breaks (DDSB) have been recognized as …

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and
Pancreatic provide recommendations for genetic testing and counseling for hereditary …

The NCCN Clinical Practice Guidelines in Oncology for Genetic/Familial High-Risk
Assessment: Breast and Ovarian provide recommendations for genetic testing and …

ABSTRACT A hereditary predisposition to breast cancer significantly influences screening
and follow-up recommendations for high-risk women. However, in patients with a suggestive …

Long-term survival rates after a diagnosis of breast cancer are steadily rising. This is good
news, but clinicians must also recognize that this brings new challenges to the medical …

Inherited loss-of-function mutations in BRCA1 and BRCA2 and other tumor suppressor
genes predispose to ovarian carcinomas, but the overall burden of disease due to inherited …

Breast cancer is the most common malignancy among females. 5%–10% of breast cancer
cases are hereditary and are caused by pathogenic mutations in the considered reference …

More than one‐fifth of ovarian tumors have hereditary susceptibility and, in about 65–85% of
these cases, the genetic abnormality is a germline mutation in BRCA genes. Nevertheless …

Breast cancer is a global burden with a woman's lifetime risk of developing breast cancer at
1 in 8. Although breast cancer is a disease that affects mostly women, the lifetime risk in men …