Computational causal modeling of the dynamic biomarker cascade in Alzheimer's disease
JR Petrella, W Hao, A Rao… - … methods in medicine, 2019 - Wiley Online Library
Background. Alzheimer's disease (AD) is a major public health concern, and there is an
urgent need to better understand its complex biology and develop effective therapies. AD …
urgent need to better understand its complex biology and develop effective therapies. AD …
Pupillary dilation responses as a midlife indicator of risk for Alzheimer's disease: association with Alzheimer's disease polygenic risk
Locus coeruleus (LC) tau accumulation begins early. Targeting LC (dys) function might
improve early identification for Alzheimer's disease (AD) risk. Pupillary responses during …
improve early identification for Alzheimer's disease (AD) risk. Pupillary responses during …
Modifying the minimum criteria for diagnosing amnestic MCI to improve prediction of brain atrophy and progression to Alzheimer's disease
Mild cognitive impairment (MCI) is a heterogeneous condition with variable outcomes.
Improving diagnosis to increase the likelihood that MCI reliably reflects prodromal …
Improving diagnosis to increase the likelihood that MCI reliably reflects prodromal …
Aβ-Positivity Predicts Cognitive Decline but Cognition Predicts Progression to Aβ-Positivity
Background Stage 1 of the NIA-AA's proposed Alzheimer's disease (AD) continuum is
defined as β-amyloid (Aβ) positive but cognitively normal. Identifying at-risk individuals …
defined as β-amyloid (Aβ) positive but cognitively normal. Identifying at-risk individuals …
[PDF][PDF] Aβ-Positivity Predicts Cognitive Decline but Cognition Also Predicts Progression to
JA Elman, MS Panizzon, DE Gustavson - hypothesis, 2008 - researchgate.net
Introduction: Biomarker positivity predicts cognitive decline and Alzheimer's dementia. But
what predicts biomarker positivity? We hypothesized that cognitive function and p-tau would …
what predicts biomarker positivity? We hypothesized that cognitive function and p-tau would …