Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against
infections and regulates the innate and acquired immune response. IL-18 is produced by …

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Initially described as an interferon (IFN) γ‐inducing factor, interleukin (IL)‐18 is indeed
involved in Th1 and NK cell activation, but also in Th2, IL‐17‐producing γδ T cells and …

Interleukin-18 (IL-18) is a member of the IL-1 family of cytokines. Similar to IL-1β, IL-18 is
synthesized as an inactive precursor requiring processing by caspase-1 into an active …

Interleukin (IL)-18 was originally discovered as a factor that enhances interferon (IFN)-γ
production by anti-CD3-stimulated Th1 cells, particularly in association with IL-12. IL-12 is a …

Induction, production, and release of proinflammatory cytokines are essential steps to
establish an effective host defense. Cytokines of the interleukin-1 (IL-1) family induce …

The gut and the liver are anatomically and physiologically connected, and this “gut–liver
axis” exerts various influences on liver pathology. The gut microbiota consists of various …

Although interleukin-18 is structurally homologous to IL-1 and its receptor belongs to the IL-
1R/Toll-like receptor (TLR) superfamily, its function is quite different from that of IL-1. IL-18 is …

The complex functions of the liver in biosynthesis, metabolism, clearance, and host defense
are tightly dependent on an adequate microcirculation. To guarantee hepatic homeostasis …

Hepatocyte death results in a sterile inflammatory response that amplifies the initial insult
and increases overall tissue injury. One important example of this type of injury is …