Iron, an essential mineral in the body, is involved in numerous physiological processes,
making the maintenance of iron homeostasis crucial for overall health. Both iron overload …

Iron is essential in many physiological processes, including DNA metabolism, oxygen
transport, and cellular energy generation. Deregulated iron metabolism, which results in iron …

Erythroferrone (ERFE) is the main erythroid regulator of hepcidin, the homeostatic hormone
controlling plasma iron levels and total body iron. When the release of erythropoietin from …

Significance: Oxygen metabolism and iron homeostasis are closely linked. Iron facilitates the
oxygen-carrying capacity of blood, and its deficiency causes anemia. Conversely, excess …

The discovery of hepcidin has provided a solid foundation for understanding the
mechanisms of systemic iron homeostasis and the aetiologies of iron disorders. Hepcidin …

The bone morphogenetic protein (BMP)-SMAD signaling pathway plays a central role in
regulating hepcidin, which is the master hormone governing systemic iron homeostasis …

Iron overload as a highly risk factor, can be found in almost all human chronic and common
diseases. Iron chelators are often used to treat iron overload; however, patient adherence to …

Erythroblasts possess unique characteristics as they undergo differentiation from
hematopoietic stem cells. During terminal erythropoiesis, these cells incorporate large …

Despite its essential role in many biological processes, iron is toxic when in excess due to its
propensity to generate reactive oxygen species. To prevent diseases associated with iron …

The hormone erythroferrone (ERFE) is produced by erythroid cells in response to
hemorrhage, hypoxia, or other erythropoietic stimuli, and it suppresses the hepatic …