Counter-regulatory renin–angiotensin system in cardiovascular disease
M Paz Ocaranza, JA Riquelme, L García… - Nature Reviews …, 2020 - nature.com
The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …
[HTML][HTML] The ACE2/angiotensin-(1–7)/MAS axis of the renin-angiotensin system: focus on angiotensin-(1–7)
RAS Santos, WO Sampaio, AC Alzamora… - Physiological …, 2017 - journals.physiology.org
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular
system and hydroelectrolyte balance, with an influence on organs and functions throughout …
system and hydroelectrolyte balance, with an influence on organs and functions throughout …
A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection
Abstract Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial
cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion …
cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers viral fusion …
ACE2 imbalance as a key player for the poor outcomes in COVID-19 patients with age-related comorbidities–role of gut microbiota dysbiosis
Abstract Coronavirus disease 19 (COVID-19) is a pandemic condition caused by the new
coronavirus SARS-CoV-2. The typical symptoms are fever, cough, shortness of breath …
coronavirus SARS-CoV-2. The typical symptoms are fever, cough, shortness of breath …
Clinical Implications of SARS-CoV-2 Interaction With Renin Angiotensin System: JACC Review Topic of the Week
A Brojakowska, J Narula, R Shimony… - Journal of the American …, 2020 - jacc.org
Severe acute respiratory-syndrome coronavirus-2 (SARS-CoV-2) host cell infection is
mediated by binding to angiotensin-converting enzyme 2 (ACE2). Systemic dysregulation …
mediated by binding to angiotensin-converting enzyme 2 (ACE2). Systemic dysregulation …
The anti-inflammatory potential of ACE2/angiotensin-(1-7)/Mas receptor axis: evidence from basic and clinical research
TR Rodrigues Prestes, NP Rocha… - Current drug …, 2017 - ingentaconnect.com
Background: The renin angiotensin system (RAS) plays an important role in inflammation
and fibrosis. The classical axis of the RAS, formed by angiotensin converting en-zyme …
and fibrosis. The classical axis of the RAS, formed by angiotensin converting en-zyme …
Angiotensin‐converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease
C Tikellis, MC Thomas - International journal of peptides, 2012 - Wiley Online Library
Angiotensin‐converting enzyme 2 (ACE2) shares some homology with angiotensin‐
converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the …
converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the …
A potential therapeutic role for angiotensin-converting enzyme 2 in human pulmonary arterial hypertension
AR Hemnes, A Rathinasabapathy… - European …, 2018 - Eur Respiratory Soc
Pulmonary arterial hypertension (PAH) is a deadly disease with no cure. Alternate
conversion of angiotensin II (AngII) to angiotensin-(1–7)(Ang-(1–7)) by angiotensin …
conversion of angiotensin II (AngII) to angiotensin-(1–7)(Ang-(1–7)) by angiotensin …
ACE2, angiotensin‐(1‐7) and M as receptor axis in inflammation and fibrosis
AC Simões e Silva, KD Silveira… - British journal of …, 2013 - Wiley Online Library
Recent advances have improved our understanding of the renin‐angiotensin system (RAS).
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …
These have included the recognition that angiotensin (A ng)‐(1‐7) is a biologically active …
New approaches in the treatment of hypertension
S Oparil, RE Schmieder - Circulation research, 2015 - Am Heart Assoc
Hypertension is the most common modifiable risk factor for cardiovascular disease and
death, and lowering blood pressure with antihypertensive drugs reduces target organ …
death, and lowering blood pressure with antihypertensive drugs reduces target organ …