Histamine and its receptors (H1R–H4R) play a crucial and significant role in the
development of various allergic diseases. Mast cells are multifunctional bone marrow …

Histamine is a developmentally highly conserved autacoid found in most vertebrate tissues.
Its physiological functions are mediated by four 7-transmembrane G protein–coupled …

Histamine acts as a modulatory neurotransmitter in the mammalian brain. It has an important
role in the maintenance of wakefulness, and dysfunction in the histaminergic system has …

Histamine, acting via distinct histamine H1, H2, H3, and H4 receptors, regulates various
physiological and pathological processes, including pain. In the last two decades, there has …

Neurotransmission is the basis of neuronal communication and is critical for normal brain
development, behavior, learning, and memory. Exposure to drugs and chemicals can alter …

The histaminergic system is exclusively localized within the posterior hypothalamus with
projection to almost all the major regions of the central nervous system. Strong and …

Considerable evidence has been collected indicating that histamine can modulate
proliferation of different normal and malignant cells. High histamine biosynthesis and …

Neuropsychiatric disorders are multifactorial disorders with diverse aetiological factors.
Identifying treatment targets is challenging because the diseases are resulting from …

The biogenic amine, histamine, has been shown to critically modulate inflammatory
processes as well as the properties of neurons and synapses in the brain, and is also …

Histamine plays important roles in inflammation and nervous irritability in allergic disorders,
including atopic dermatitis (AD). It has been shown to regulate the expression of pruritic …