Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Aging is characterized by a progressive decline of physiological integrity leading to the loss
of tissue function and vulnerability to disease, but its causes remain poorly understood …

Background Investigations into both the pathophysiology and therapeutic targets in muscle
dystrophies have been hampered by the limited proliferative capacity of human myoblasts …

Muscle stem cells, the engine of muscle repair, are affected in myotonic dystrophy type 1
(DM1); however, the underlying molecular mechanism and the impact on the disease …

Skeletal muscle fibres are multinucleated cells that contain postmitotic nuclei (ie they are no
longer able to divide) and perform muscle contraction. They are formed by fusion of muscle …

ABSTRACT Myotonic dystrophy type 1 (DM1) is the most prevalent form of muscular
dystrophy in adults and yet there are currently no treatment options. Although this disease …

Cardiac disease is a common clinical manifestation of neuromuscular disorders, particularly
of muscular dystrophies. Heart muscle cells as well as specialized conducting myocardial …

Skeletal muscle mass and function decline with aging, a process known as sarcopenia,
which restrains posture maintenance, mobility and quality of life in the elderly. Sarcopenia is …

Myotonic dystrophy type 1 (DM1 or Steinert's disease) and type 2 (DM2) are multisystem
disorders of genetic origin. Progressive muscular weakness, atrophy and myotonia are the …

Although adult skeletal muscle is composed of fully differentiated fibers, it retains the
capacity to regenerate in response to injury and to modify its contractile and metabolic …