Small molecule mediators of host-T. cruzi-environment interactions in Chagas disease
G Kwakye-Nuako, CE Middleton, LI McCall - PLoS Pathogens, 2024 - journals.plos.org
Small molecules (less than 1,500 Da) include major biological signals that mediate host-
pathogen-microbiome communication. They also include key intermediates of metabolism …
pathogen-microbiome communication. They also include key intermediates of metabolism …
Mitochondrial adaptations throughout the Trypanosoma brucei life cycle
A Zíková - Journal of Eukaryotic Microbiology, 2022 - Wiley Online Library
The unicellular parasite Trypanosoma brucei has a digenetic life cycle that alternates
between a mammalian host and an insect vector. During programmed development, this …
between a mammalian host and an insect vector. During programmed development, this …
Branched-chain amino acids modulate the proteomic profile of Trypanosoma cruzi metacyclogenesis induced by proline
JF Nascimento, FS Damasceno… - PLOS Neglected …, 2024 - journals.plos.org
Trypanosoma cruzi, the causative agent of Chagas disease, has a complex life cycle that
involves triatomine insects as vectors and mammals as hosts. The differentiation of …
involves triatomine insects as vectors and mammals as hosts. The differentiation of …
The branched chain amino acids (BCAAs) modulate the development of the intra-cellular stages of Trypanosoma cruzi
LN Rapado, JF Nascimento, NC Manchola… - Experimental …, 2023 - Elsevier
The life cycle of Trypanosoma cruzi, the etiological agent of Chagas disease, involves
different forms of the parasite, which alternates between insect and vertebrate hosts. One …
different forms of the parasite, which alternates between insect and vertebrate hosts. One …
Genetic and functional dissection of the glutamate-proline pathway reveals a shortcut for glutamate catabolism in Leishmania
GD Campagnaro, AK Cruz - bioRxiv, 2024 - biorxiv.org
Trypanosomatids are early-divergent eukaryotes that have adapted to parasitism. During
their life cycles, these parasites switch between a mammalian and an invertebrate host, and …
their life cycles, these parasites switch between a mammalian and an invertebrate host, and …
Branched chain amino acids modulate the proteomic profile of Pro-induced differentiation for the infective stages of Trypanosoma cruzi
J De Freitas Nascimento, FS Damasceno… - bioRxiv, 2024 - biorxiv.org
Trypanosoma cruzi, the causative agent of Chagas disease, undergoes a complex life cycle
involving triatomine insects as vectors and mammals. The differentiation of epimastigote …
involving triatomine insects as vectors and mammals. The differentiation of epimastigote …