Metabolites of glycolytic metabolism have been identified as signaling molecules and
regulators of gene expression, in addition to their basic function as major energy and …

Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

Lactate dehydrogenase (LDH) is a terminating enzyme in the metabolic pathway of
anaerobic glycolysis with end product of lactate from glucose. The lactate formation is crucial …

For decades, lactate has been considered an innocuous bystander metabolite of cellular
metabolism. However, emerging studies show that lactate acts as a complex …

Cancer is a metabolic disease in which abnormally proliferating cancer cells rewire
metabolic pathways in the tumor microenvironment (TME). Molecular reprogramming in the …

Purpose Prostate cancer (PCa) is one of the most common malignancies in males. Despite
the success of immunotherapy in many malignant cancers, strategies are still needed to …

Allergic asthma is a disease initiated by a breach of the lung mucosal barrier and an
inappropriate Th2 inflammatory immune response that results in M2 polarization of alveolar …

African American men in the United States have higher mortality due to prostate cancer
(PCa) compared to other races. One reason for this disparity is the lack of in-depth …

Background We aimed to construct and validate an energy metabolism-related gene
prognostic index (EMRGPI) to predict biochemical recurrence (BCR) in patients undergoing …

Immunotherapy is a revolutionary achievement in cancer treatment. However, inadequate
immune cells infiltration in tumor microenvironment (TME) always leads to treatment failure …