The continued threat of emerging flaviviruses

TC Pierson, MS Diamond - Nature microbiology, 2020 - nature.com
Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human
populations and cause a spectrum of potentially severe diseases including hepatitis …

Combating mosquito-borne diseases using genetic control technologies

GH Wang, S Gamez, RR Raban, JM Marshall… - Nature …, 2021 - nature.com
Mosquito-borne diseases, such as dengue and malaria, pose significant global health
burdens. Unfortunately, current control methods based on insecticides and environmental …

Development of a confinable gene drive system in the human disease vector Aedes aegypti

M Li, T Yang, NP Kandul, M Bui, S Gamez, R Raban… - Elife, 2020 - elifesciences.org
Aedes aegypti is the principal mosquito vector for many arboviruses that increasingly infect
millions of people every year. With an escalating burden of infections and the relative failure …

Inherently confinable split-drive systems in Drosophila

G Terradas, AB Buchman, JB Bennett, I Shriner… - Nature …, 2021 - nature.com
CRISPR-based gene-drive systems, which copy themselves via gene conversion mediated
by the homology-directed repair (HDR) pathway, have the potential to revolutionize vector …

Manipulating the destiny of wild populations using CRISPR

R Raban, JM Marshall, BA Hay… - Annual review of …, 2023 - annualreviews.org
Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Broad dengue neutralization in mosquitoes expressing an engineered antibody

A Buchman, S Gamez, M Li, I Antoshechkin… - PLoS …, 2020 - journals.plos.org
With dengue virus (DENV) becoming endemic in tropical and subtropical regions worldwide,
there is a pressing global demand for effective strategies to control the mosquitoes that …

A Review: Wolbachia-Based Population Replacement for Mosquito Control Shares Common Points with Genetically Modified Control Approaches

PS Yen, AB Failloux - Pathogens, 2020 - mdpi.com
The growing expansion of mosquito vectors has made mosquito-borne arboviral diseases a
global threat to public health, and the lack of licensed vaccines and treatments highlight the …

Advances and challenges in synthetic biology for mosquito control

SC Weng, RA Masri, OS Akbari - Trends in parasitology, 2024 - cell.com
Mosquito-borne illnesses represent a significant global health peril, resulting in
approximately one million fatalities annually. West Nile, dengue, Zika, and malaria are …

Assessment of a split homing based gene drive for efficient knockout of multiple genes

NP Kandul, J Liu, A Buchman, VM Gantz… - G3: Genes …, 2020 - academic.oup.com
Homing based gene drives (HGD) possess the potential to spread linked cargo genes into
natural populations and are poised to revolutionize population control of animals. Given that …

Essential oils and their chemical constituents against Aedes aegypti L.(Diptera: Culicidae) larvae

TRSA Luz, LSS de Mesquita, FMM do Amaral… - Acta Tropica, 2020 - Elsevier
This review focused on the toxicity of essential oils and their constituents against Aedes
aegypti L.(Diptera, Culicidae) larvae, a key vector of important arboviral diseases, such as …