The insulin-like growth factor (IGF) family of ligands, binding proteins and receptors is an
important growth factor system involved in both the development of the organism and the …

Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in
multiple aspects of growth, development and metabolism. The biological actions of IGF1 are …

The insulin-like growth factor-1 receptor (IGF-1R) plays a pivotal role in transformation,
growth, and survival of malignant cells, and has emerged as a general and promising target …

The insulin-like growth factor type 1 receptor (IGF-1R) plays a key role in the development
and progression of cancer; however, therapeutics targeting it have had disappointing results …

In light of the continuing need for effective anticancer agents, and the association of fruit and
vegetable consumption with reduced cancer risk, edible plants are increasingly being …

The MAGE gene family is characterized by a conserved domain (MAGE Homology Domain).
A subset of highly homologous MAGE genes (group A; MAGE-A) belong to the chromosome …

Abstract GH and IGF-I and-II were first identified by their endocrine activity. Specifically, IGF-I
was found to mediate the linear growth-promoting actions of GH. It is now evident that these …

Purpose: Pediatric gastrointestinal stromal tumors (GIST) are rare and occur preferentially in
females as multifocal gastric tumors, typically lacking mutations in KIT and PDGFRA. As KIT …

The insulin-like growth factor (IGF-1) signalling is highly implicated in cancer. In this
signalling the IGF-1 receptor (IGF-1R) is unquestionable, the predominating single factor …

Recently, p53 was demonstrated to affect the expression of the insulin-like growth factor 1
receptor (IGF-1R), a receptor tyrosine kinase that plays a crucial role in growth and survival …