Despite the emergence of cutting-edge therapeutic strategies and tremendous progress in
research, a complete cure of glioma remains elusive. The heterogenous nature of tumor …

Nucleic acid therapeutics have emerged as one of the very advanced and efficacious
treatment approaches for debilitating health conditions, including those diseases affecting …

The clinical translation of therapeutic approaches to combat debilitating neurodegenerative
conditions, such as Parkinson's disease (PD), remains as an urgent unmet challenge. The …

The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the
homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult …

Drug addiction is a serious problem globally, recently exacerbated by the COVID-19
pandemic. Glial cell-derived neurotrophic factor (GDNF) is considered a potentially effective …

Introduction Neurodegenerative diseases are those wherein the neurons in the brain or
peripheral nervous system lose their function, eventually culminating in neuronal death …

Since the elucidation of its structure, DNA has been at the forefront of biological research. In
the past half century, an explosion of DNA‐based technology development has occurred …

Delivering therapeutics across the blood-brain barrier (BBB) for treating central nervous
system (CNS) diseases is one of the biggest challenges today as the BBB limits the uptake …

Parkinson's disease (PD) is characterized by loss of dopaminergic neurons, oxidative stress
and neuroinflammation. The classical therapeutic approach with L-DOPA is not able to …

CNS disorders represent neurological disorders that affect either the structure or function of
the brain or spinal cord. CNS diseases include Alzheimer's disease, Parkinson's disease …