Triosephosphate isomerase (TIM) is a perfectly evolved enzyme which very fast
interconverts dihydroxyacetone phosphate and d-glyceraldehyde-3-phosphate. Its catalytic …

Rapid progress in biological sensing and imaging technologies offers new and exciting
opportunities to identify biochemical changes fundamental to preclinical research that may …

Traditionally, transition metal–catalyzed enantioselective transformations rely on chiral
ligands tightly bound to the metal to induce asymmetric product distributions. Here we report …

Many studies have implicated a role for conformational motions during the catalytic cycle,
acting to optimize the binding pocket or facilitate product release, but a more intimate role in …

Products of unfavorable chemical equilibria are not readily observed because their high
energy and increased reactivity result in low concentrations. Biological macromolecules use …

The activation energy barrier of biochemical reactions is normally lowered by an enzyme
catalyst, which directly helps the weakening of the bond (s) to be broken. In many …

The transition element molybdenum (Mo) needs to be complexed by a special cofactor in
order to gain catalytic activity. With the exception of bacterial Mo-nitrogenase, where Mo is a …

Biological activity is governed by the timely redistribution of molecular interactions, and static
structural snapshots often appear insufficient to provide the molecular determinants that …

Rhizoctonia solani Kuhn causes sheath blight disease in rice, and genetic resistance
against it is the most desirable characteristic. Current improvement efforts are based on …

Caldicellulosiruptor bescii is an extremely thermophilic, cellulolytic bacterium with a growth
optimum at 78° C and is the most thermophilic cellulose degrader known. It is an attractive …