Towards clinical translation of FLASH radiotherapy
MC Vozenin, J Bourhis, M Durante - Nature Reviews Clinical Oncology, 2022 - nature.com
The ultimate goal of radiation oncology is to eradicate tumours without toxicity to non-
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
malignant tissues. FLASH radiotherapy, or the delivery of ultra-high dose rates of radiation …
Reinventing radiobiology in the light of FLASH radiotherapy
CL Limoli, MC Vozenin - Annual Review of Cancer Biology, 2023 - annualreviews.org
Ultrahigh–dose rate FLASH radiotherapy (FLASH-RT) is a potentially paradigm-shifting
treatment modality that holds the promise of expanding the therapeutic index for nearly any …
treatment modality that holds the promise of expanding the therapeutic index for nearly any …
FLASH with carbon ions: Tumor control, normal tissue sparing, and distal metastasis in a mouse osteosarcoma model
W Tinganelli, U Weber, A Puspitasari… - Radiotherapy and …, 2022 - Elsevier
Background and purpose The FLASH effect is a potential breakthrough in radiotherapy
because ultra-high dose-rate irradiation can substantially widen the therapeutic window …
because ultra-high dose-rate irradiation can substantially widen the therapeutic window …
FLASH: New intersection of physics, chemistry, biology, and cancer medicine
Ultrahigh dose rate, FLASH radiotherapy has emerged as one of the most promising
innovations over the past decade in the field of radiation oncology, with the potential to …
innovations over the past decade in the field of radiation oncology, with the potential to …
Dual beam‐current transformer design for monitoring and reporting of electron ultra‐high dose rate (FLASH) beam parameters
Purpose To investigate the usefulness and effectiveness of a dual beam‐current transformer
(BCTs) design to monitor and record the beam dosimetry output and energy of pulsed …
(BCTs) design to monitor and record the beam dosimetry output and energy of pulsed …
[HTML][HTML] A new solution for UHDP and UHDR (Flash) measurements: Theory and conceptual design of ALLS chamber
Ultra-High dose-per-pulse regimens (UHDP), necessary to trigger the “FLASH” effect, still
pose serious challenges to dosimetry. Dosimetry plays a crucial role, both to significantly …
pose serious challenges to dosimetry. Dosimetry plays a crucial role, both to significantly …
Flash radiotherapy: Innovative cancer treatment
JCL Chow, HE Ruda - Encyclopedia, 2023 - mdpi.com
Definition Flash radiotherapy (Flash-RT) is an innovative technique used in radiotherapy for
cancer treatment because it delivers an extremely high dose of radiation (> 40 Gy/s) to the …
cancer treatment because it delivers an extremely high dose of radiation (> 40 Gy/s) to the …
[HTML][HTML] Framework for quality assurance of ultrahigh dose rate clinical trials investigating FLASH effects and current technology gaps
Abstract FLASH radiation therapy (FLASH-RT), delivered with ultrahigh dose rate (UHDR),
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …
may allow patients to be treated with less normal tissue toxicity for a given tumor dose …
[HTML][HTML] FLASH radiotherapy treatment planning and models for electron beams
M Rahman, A Trigilio, G Franciosini, R Moeckli… - Radiotherapy and …, 2022 - Elsevier
The FLASH effect designates normal tissue sparing at ultra-high dose rate (UHDR,> 40
Gy/s) compared to conventional dose rate (∼ 0.1 Gy/s) irradiation while maintaining tumour …
Gy/s) compared to conventional dose rate (∼ 0.1 Gy/s) irradiation while maintaining tumour …
Independent reproduction of the FLASH effect on the gastrointestinal tract: a multi-institutional comparative study
Simple Summary The ability of ultra-high dose rate FLASH radiation therapy (RT) to reduce
normal tissue toxicity without affecting tumor response relative to conventional dose rate …
normal tissue toxicity without affecting tumor response relative to conventional dose rate …