Singlet oxygen (1O2) is a biologically relevant reactive oxygen species capable of efficiently
reacting with cellular constituents. The resulting oxidatively generated damage to nucleic …

The use of non-toxic dyes or photosensitizers (PS) in combination with harmless visible light
that is known as photodynamic therapy (PDT) has been known for over a hundred years, but …

Infections caused by drug-resistant pathogens are rapidly increasing in incidence and pose
an urgent global health concern. New treatments are needed to address this critical situation …

Nitric oxide is a key participant in many physiological pathways; however, its reactivity gives
it the potential to cause considerable damage to cells and tissues in its vicinity. Nitric oxide …

Revised and updated, Chemical Reagents for Protein Modification, Third Edition is an
encyclopedic work describing the many approaches to the site-specific modification of …

Deoxyribonucleic acid (DNA) appears to be a critical cellular target for the biological effects
(cellular lethality, mutagenesis, carcinogenesis, and ageing) of oxidation processes …

Introduction Oxidative damage to DNA in vivo can lead to mutations and cancer. DNA
damage and repair studies have not yet revealed whether permanent oxidative lesions are …

Further oxidation of the common DNA lesion 8-oxo-7, 8-dihydroguanosine by one-electron
oxidants such as IrCl62-, Fe (CN) 63-, or SO4-• leads to two major products, depending …

Use of one-electron oxidants such as Na2IrCl6 to oxidize 8-oxo-7, 8-dihydro-2 '-
deoxyguanosine (OG) residues in oligodeoxynucleotides was previously shown to lead to …

This survey focuses on recent aspects of the singlet oxygen oxidation of the guanine moiety
of nucleosides, oligonucleotides, isolated and cellular DNA that has been shown to be the …