The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

J. Neurochem.(2012) 120 (Suppl. 1), 9–21. Abstract β‐Amyloid precursor protein (APP) is a
critical factor in the pathogenesis of Alzheimer's disease (AD). APP undergoes post …

Prion diseases are transmissible spongiform encephalopathies (TSEs), attributed to
conformational conversion of the cellular prion protein (PrPC) into an abnormal conformer …

Proteins belonging to the 'A Disintegrin And Metalloproteinase'(ADAM) family are membrane-
anchored proteases that are able to cleave the extracellular domains of several membrane …

Abstract 'A disintegrin and metalloproteases'(ADAMs) are a family of transmembrane
proteins with diverse functions in multicellular organisms. About half of the ADAMs are active …

The 'A Disintegrin And Metalloproteinase 10'(ADAM10) has gained considerable attention
due to its discovery as an 'α‐secretase'involved in the nonamyloidogenic processing of the …

CD44 is a cell surface adhesion molecule for hyaluronan and is implicated in tumor invasion
and metastasis. Proteolytic cleavage of CD44 plays a critical role in the migration of tumor …

Recently, we have shown that green tea polyphenol (–)-epigallocatechin-3-gallate (EGCG)
exerts a beneficial role on reducing brain Aβ levels, resulting in mitigation of cerebral …

ADAM (a disintegrin and metalloproteinase) is a family of widely expressed, transmembrane
and secreted proteins of approximately 750 amino acids in length with functions in cell …

The cellular prion protein (PrP C) is essential for the pathogenesis and transmission of prion
diseases. PrP C is bound to the plasma membrane via a glycosylphosphatidylinositol …