[HTML][HTML] NK cell development, homeostasis and function: parallels with CD8+ T cells

JC Sun, LL Lanier - Nature Reviews Immunology, 2011 - nature.com
Natural killer (NK) cells survey host tissues for signs of infection, transformation or stress
and, true to their name, kill target cells that have become useless or are detrimental to the …

Transcription factors associated with IL-15 cytokine signaling during NK cell development

X Wang, XY Zhao - Frontiers in immunology, 2021 - frontiersin.org
Natural killer (NK) cells are lymphocytes primarily involved in innate immunity and possess
important functional properties in anti-viral and anti-tumor responses; thus, these cells have …

IL‐15: a central regulator of celiac disease immunopathology

V Abadie, B Jabri - Immunological reviews, 2014 - Wiley Online Library
Summary Interleukin‐15 (IL‐15) exerts many biological functions essential for the
maintenance and function of multiple cell types. Although its expression is tightly regulated …

[HTML][HTML] The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use

PY Perera, JH Lichy, TA Waldmann, LP Perera - Microbes and Infection, 2012 - Elsevier
Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in
many diverse cell types. It plays a major role in the development of inflammatory and …

IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses

RM Santana Carrero… - Proceedings of the …, 2019 - National Acad Sciences
Previous studies have provided evidence that IL-15 expression within human tumors is
crucial for optimal antitumor responses; however, the regulation of IL-15 within the tumor …

M‐CSF directs myeloid and NK cell differentiation to protect from CMV after hematopoietic cell transplantation

PK Kandalla, J Subburayalu, C Cocita… - EMBO Molecular …, 2023 - embopress.org
Therapies reconstituting autologous antiviral immunocompetence may represent an
important prophylaxis and treatment for immunosuppressed individuals. Following …

IL-2 and beyond in cancer immunotherapy

JM Wrangle, A Patterson, CB Johnson… - Journal of Interferon & …, 2018 - liebertpub.com
The development of the T-and natural killer (NK) cell growth factor IL-2 has been a sentinel
force ushering in the era of immunotherapy in cancer. With the advent of clinical grade …

Immunotherapy: a promising approach to reverse sepsis-induced immunosuppression

NK Patil, JK Bohannon, ER Sherwood - Pharmacological Research, 2016 - Elsevier
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
responses to infection (Third International Consensus definition for Sepsis and septic …

Regulation of mouse NK cell development and function by cytokines

A Marçais, S Viel, M Grau, T Henry, J Marvel… - Frontiers in …, 2013 - frontiersin.org
Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense
against intracellular pathogens and against tumors. Like other immune cells, almost every …

Trans-presentation: a novel mechanism regulating IL-15 delivery and responses

SW Stonier, KS Schluns - Immunology letters, 2010 - Elsevier
Interleukin (IL)-15 is a cytokine that acts on a wide range of cell types but is most crucial for
the development, homeostasis, and function of a specific group of immune cells that …