A review on advances of treatment modalities for Alzheimer's disease

ES Thoe, A Fauzi, YQ Tang, S Chamyuang, AYY Chia - Life sciences, 2021 - Elsevier
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease which is mainly
characterized by progressive impairment in cognition, emotion, language and memory in …

Self-assembled peptide-based nanostructures: Smart nanomaterials toward targeted drug delivery

N Habibi, N Kamaly, A Memic, H Shafiee - Nano today, 2016 - Elsevier
Self-assembly of peptides can yield an array of well-defined nanostructures that are highly
attractive nanomaterials for many biomedical applications such as drug delivery. Some of …

Improving cellular uptake of therapeutic entities through interaction with components of cell membrane

R Zhang, X Qin, F Kong, P Chen, G Pan - Drug Delivery, 2019 - Taylor & Francis
Efficient cellular delivery of biologically active molecules is one of the key factors that affect
the discovery and development of novel drugs. The plasma membrane is the first barrier that …

[HTML][HTML] Cell-penetrating peptides: Design strategies beyond primary structure and amphipathicity

D Kalafatovic, E Giralt - molecules, 2017 - mdpi.com
Efficient intracellular drug delivery and target specificity are often hampered by the presence
of biological barriers. Thus, compounds that efficiently cross cell membranes are the key to …

[HTML][HTML] Applications and challenges for use of cell-penetrating peptides as delivery vectors for peptide and protein cargos

M Kristensen, D Birch, H Mørck Nielsen - International journal of …, 2016 - mdpi.com
The hydrophilic nature of peptides and proteins renders them impermeable to cell
membranes. Thus, in order to successfully deliver peptide and protein-based therapeutics …

[HTML][HTML] Molecular mechanisms and biological functions of siRNA

H Dana, GM Chalbatani… - … journal of biomedical …, 2017 - ncbi.nlm.nih.gov
One of the most important advances in biology has been the discovery that siRNA (small
interfering RNA) is able to regulate the expression of genes, by a phenomenon known as …

Twenty years of cell‐penetrating peptides: from molecular mechanisms to therapeutics

F Heitz, MC Morris, G Divita - British journal of pharmacology, 2009 - Wiley Online Library
The recent discovery of new potent therapeutic molecules that do not reach the clinic due to
poor delivery and low bioavailability have made of delivery a key stone in therapeutic …

[HTML][HTML] Peptide-based drug-delivery systems in biotechnological applications: recent advances and perspectives

D Tesauro, A Accardo, C Diaferia, V Milano, J Guillon… - Molecules, 2019 - mdpi.com
Peptides of natural and synthetic sources are compounds operating in a wide range of
biological interactions. They play a key role in biotechnological applications as both …

pH-and ion-sensitive polymers for drug delivery

T Yoshida, TC Lai, GS Kwon, K Sako - Expert opinion on drug …, 2013 - Taylor & Francis
Introduction: Drug delivery systems (DDSs) are important for effective, safe, and convenient
administration of drugs. pH-and ion-responsive polymers have been widely employed in …

Surface engineering of inorganic nanoparticles for imaging and therapy

J Nam, N Won, J Bang, H Jin, J Park, S Jung… - Advanced drug delivery …, 2013 - Elsevier
Many kinds of inorganic nanoparticles (NPs) including semiconductor, metal, metal oxide,
and lanthanide-doped NPs have been developed for imaging and therapy applications …