Background The clinical high‐risk state for psychosis (CHR‐P) paradigm has facilitated the
implementation of psychosis prevention into clinical practice; however, advancements in …

People with psychotic disorders show abnormalities in several organ systems in addition to
the central nervous system (CNS); and this contributes to excess mortality. However, it is …

Importance Detection, prognosis, and indicated interventions in individuals at clinical high
risk for psychosis (CHR-P) are key components of preventive psychiatry. Objective To …

Hippocampal volume is a marker of brain health and is reduced with aging and neurological
disease. Exercise may be effective at increasing and preserving hippocampal volume …

The introduction of clinical criteria for the operationalization of psychosis high risk provided a
basis for early detection and treatment of vulnerable individuals. However, about two-thirds …

Schizophrenia is a grave neuropsychiatric disease which frequently onsets between the end
of adolescence and the beginning of adulthood. It is characterized by a variety of …

Despite strong evidence of the neurodevelopmental origins of psychosis, current
pharmacological treatment is not usually initiated until after a clinical diagnosis is made, and …

To date, a large number of magnetic resonance imaging (MRI) studies have been conducted
in schizophrenia, which generally demonstrate gray matter reduction, predominantly in the …

Cross-sectional studies suggest that hippocampal volume declines across stages of
psychosis. In contrast, longitudinal studies indicate that hippocampal volume is stable in the …

Schizophrenia is a highly heritable disorder for which anatomical brain alterations have
been repeatedly reported in clinical samples. Unaffected at-risk groups have also been …